Common variants at 19p13 are associated with susceptibility to ovarian cancer

Kelly L Bolton; Jonathan Tyrer; Honglin Song; Susan J Ramus; Maria Notaridou; Chris Jones; Tanya Sher; Aleksandra Gentry-Maharaj; Eva Wozniak; Ya-Yu Tsai; Joanne Weidhaas; Daniel Paik; David J Van Den Berg; Daniel O Stram; Celeste Leigh Pearce; Anna H Wu; Wendy Brewster; Hoda Anton-Culver; Argyrios Ziogas; Steven A Narod; Douglas A Levine; Stanley B Kaye; Robert Brown; Jim Paul; James Flanagan; Weiva Sieh; Valerie McGuire; Alice S Whittemore; Ian Campbell; Martin E Gore; Jolanta Lissowska; Hanna P Yang; Krzysztof Medrek; Jacek Gronwald; Jan Lubinski; Anna Jakubowska; Nhu D Le; Linda S Cook; Linda E Kelemen; Angela Brook-Wilson; Leon F A G Massuger; Lambertus A Kiemeney; Katja K H Aben; Anne M van Altena; Richard Houlston; Ian Tomlinson; Rachel T Palmieri; Patricia G Moorman; Estrid Vilma Solyom Høgdall; Claus Hogdall; Australian Ovarian Cancer Study Group

doi:http://dx.doi.org/10.1038/ng.666

Common variants at 19p13 are associated with susceptibility to ovarian cancer

Kelly L Bolton, Jonathan Tyrer, Honglin Song, Susan J Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry-Maharaj, Eva Wozniak, Ya-Yu Tsai, Joanne Weidhaas, Daniel Paik, David J Van Den Berg, Daniel O Stram, Celeste Leigh Pearce, Anna H Wu, Wendy Brewster, Hoda Anton-Culver, Argyrios Ziogas, Steven A NarodDouglas A Levine, Stanley B Kaye, Robert Brown, Jim Paul, James Flanagan, Weiva Sieh, Valerie McGuire, Alice S Whittemore, Ian Campbell, Martin E Gore, Jolanta Lissowska, Hanna P Yang, Krzysztof Medrek, Jacek Gronwald, Jan Lubinski, Anna Jakubowska, Nhu D Le, Linda S Cook, Linda E Kelemen, Angela Brook-Wilson, Leon F A G Massuger, Lambertus A Kiemeney, Katja K H Aben, Anne M van Altena, Richard Houlston, Ian Tomlinson, Rachel T Palmieri, Patricia G Moorman, Estrid Vilma Solyom Høgdall, Claus Hogdall, Australian Ovarian Cancer Study Group

Faculty of Health and Medical Sciences

Research output: Contribution to journal › Journal article › Research › peer-review

222 Citations (Scopus)

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

Original language	English
Journal	Nature Genetics
Volume	42
Issue number	10
Pages (from-to)	880-4
Number of pages	5
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.666
Publication status	Published - 1 Oct 2010

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Bolton, K. L., Tyrer, J., Song, H., Ramus, S. J., Notaridou, M., Jones, C., Sher, T., Gentry-Maharaj, A., Wozniak, E., Tsai, Y-Y., Weidhaas, J., Paik, D., Van Den Berg, D. J., Stram, D. O., Pearce, C. L., Wu, A. H., Brewster, W., Anton-Culver, H., Ziogas, A., ... Australian Ovarian Cancer Study Group (2010). Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nature Genetics, 42(10), 880-4. https://doi.org/10.1038/ng.666

Common variants at 19p13 are associated with susceptibility to ovarian cancer. / Bolton, Kelly L; Tyrer, Jonathan; Song, Honglin; Ramus, Susan J; Notaridou, Maria; Jones, Chris; Sher, Tanya; Gentry-Maharaj, Aleksandra; Wozniak, Eva; Tsai, Ya-Yu; Weidhaas, Joanne; Paik, Daniel; Van Den Berg, David J; Stram, Daniel O; Pearce, Celeste Leigh; Wu, Anna H; Brewster, Wendy; Anton-Culver, Hoda; Ziogas, Argyrios; Narod, Steven A; Levine, Douglas A; Kaye, Stanley B; Brown, Robert; Paul, Jim; Flanagan, James; Sieh, Weiva; McGuire, Valerie; Whittemore, Alice S; Campbell, Ian; Gore, Martin E; Lissowska, Jolanta; Yang, Hanna P; Medrek, Krzysztof; Gronwald, Jacek; Lubinski, Jan; Jakubowska, Anna; Le, Nhu D; Cook, Linda S; Kelemen, Linda E; Brook-Wilson, Angela; Massuger, Leon F A G; Kiemeney, Lambertus A; Aben, Katja K H; van Altena, Anne M; Houlston, Richard; Tomlinson, Ian; Palmieri, Rachel T; Moorman, Patricia G; Høgdall, Estrid Vilma Solyom ; Hogdall, Claus; Australian Ovarian Cancer Study Group.

In: Nature Genetics, Vol. 42, No. 10, 01.10.2010, p. 880-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Bolton, KL, Tyrer, J, Song, H, Ramus, SJ, Notaridou, M, Jones, C, Sher, T, Gentry-Maharaj, A, Wozniak, E, Tsai, Y-Y, Weidhaas, J, Paik, D, Van Den Berg, DJ, Stram, DO, Pearce, CL, Wu, AH, Brewster, W, Anton-Culver, H, Ziogas, A, Narod, SA, Levine, DA, Kaye, SB, Brown, R, Paul, J, Flanagan, J, Sieh, W, McGuire, V, Whittemore, AS, Campbell, I, Gore, ME, Lissowska, J, Yang, HP, Medrek, K, Gronwald, J, Lubinski, J, Jakubowska, A, Le, ND, Cook, LS, Kelemen, LE, Brook-Wilson, A, Massuger, LFAG, Kiemeney, LA, Aben, KKH, van Altena, AM, Houlston, R, Tomlinson, I, Palmieri, RT, Moorman, PG, Høgdall, EVS , Hogdall, C & Australian Ovarian Cancer Study Group 2010, 'Common variants at 19p13 are associated with susceptibility to ovarian cancer', Nature Genetics, vol. 42, no. 10, pp. 880-4. https://doi.org/10.1038/ng.666

Bolton, Kelly L ; Tyrer, Jonathan ; Song, Honglin ; Ramus, Susan J ; Notaridou, Maria ; Jones, Chris ; Sher, Tanya ; Gentry-Maharaj, Aleksandra ; Wozniak, Eva ; Tsai, Ya-Yu ; Weidhaas, Joanne ; Paik, Daniel ; Van Den Berg, David J ; Stram, Daniel O ; Pearce, Celeste Leigh ; Wu, Anna H ; Brewster, Wendy ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Narod, Steven A ; Levine, Douglas A ; Kaye, Stanley B ; Brown, Robert ; Paul, Jim ; Flanagan, James ; Sieh, Weiva ; McGuire, Valerie ; Whittemore, Alice S ; Campbell, Ian ; Gore, Martin E ; Lissowska, Jolanta ; Yang, Hanna P ; Medrek, Krzysztof ; Gronwald, Jacek ; Lubinski, Jan ; Jakubowska, Anna ; Le, Nhu D ; Cook, Linda S ; Kelemen, Linda E ; Brook-Wilson, Angela ; Massuger, Leon F A G ; Kiemeney, Lambertus A ; Aben, Katja K H ; van Altena, Anne M ; Houlston, Richard ; Tomlinson, Ian ; Palmieri, Rachel T ; Moorman, Patricia G ; Høgdall, Estrid Vilma Solyom ; Hogdall, Claus ; Australian Ovarian Cancer Study Group. / Common variants at 19p13 are associated with susceptibility to ovarian cancer. In: Nature Genetics. 2010 ; Vol. 42, No. 10. pp. 880-4.

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title = "Common variants at 19p13 are associated with susceptibility to ovarian cancer",

abstract = "Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.",

author = "Bolton, {Kelly L} and Jonathan Tyrer and Honglin Song and Ramus, {Susan J} and Maria Notaridou and Chris Jones and Tanya Sher and Aleksandra Gentry-Maharaj and Eva Wozniak and Ya-Yu Tsai and Joanne Weidhaas and Daniel Paik and {Van Den Berg}, {David J} and Stram, {Daniel O} and Pearce, {Celeste Leigh} and Wu, {Anna H} and Wendy Brewster and Hoda Anton-Culver and Argyrios Ziogas and Narod, {Steven A} and Levine, {Douglas A} and Kaye, {Stanley B} and Robert Brown and Jim Paul and James Flanagan and Weiva Sieh and Valerie McGuire and Whittemore, {Alice S} and Ian Campbell and Gore, {Martin E} and Jolanta Lissowska and Yang, {Hanna P} and Krzysztof Medrek and Jacek Gronwald and Jan Lubinski and Anna Jakubowska and Le, {Nhu D} and Cook, {Linda S} and Kelemen, {Linda E} and Angela Brook-Wilson and Massuger, {Leon F A G} and Kiemeney, {Lambertus A} and Aben, {Katja K H} and {van Altena}, {Anne M} and Richard Houlston and Ian Tomlinson and Palmieri, {Rachel T} and Moorman, {Patricia G} and H{\o}gdall, {Estrid Vilma Solyom} and Claus Hogdall and H{\o}gdall, {Claus Kim}",

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AU - Bolton, Kelly L

AU - Tyrer, Jonathan

AU - Song, Honglin

AU - Ramus, Susan J

AU - Notaridou, Maria

AU - Jones, Chris

AU - Sher, Tanya

AU - Gentry-Maharaj, Aleksandra

AU - Wozniak, Eva

AU - Tsai, Ya-Yu

AU - Weidhaas, Joanne

AU - Paik, Daniel

AU - Van Den Berg, David J

AU - Stram, Daniel O

AU - Pearce, Celeste Leigh

AU - Wu, Anna H

AU - Brewster, Wendy

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Narod, Steven A

AU - Levine, Douglas A

AU - Kaye, Stanley B

AU - Brown, Robert

AU - Paul, Jim

AU - Flanagan, James

AU - Sieh, Weiva

AU - McGuire, Valerie

AU - Whittemore, Alice S

AU - Campbell, Ian

AU - Gore, Martin E

AU - Lissowska, Jolanta

AU - Yang, Hanna P

AU - Medrek, Krzysztof

AU - Gronwald, Jacek

AU - Lubinski, Jan

AU - Jakubowska, Anna

AU - Le, Nhu D

AU - Cook, Linda S

AU - Kelemen, Linda E

AU - Brook-Wilson, Angela

AU - Massuger, Leon F A G

AU - Kiemeney, Lambertus A

AU - Aben, Katja K H

AU - van Altena, Anne M

AU - Houlston, Richard

AU - Tomlinson, Ian

AU - Palmieri, Rachel T

AU - Moorman, Patricia G

AU - Høgdall, Estrid Vilma Solyom

AU - Hogdall, Claus

AU - Australian Ovarian Cancer Study Group

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N2 - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

AB - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

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SP - 880

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JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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