Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Connie Bezzina; Julien Barc; Yuka Mizusawa; Carol Ann Remme; Jean-Baptiste Gourraud; Floriane Simonet; Arie O Verkerk; Peter J Schwartz; Lia Crotti; Federica Dagradi; Pascale Guicheney; Véronique Fressart; Antoine Leenhardt; Charles Antzelevitch; Susan Bartkowiak; Martin Borggrefe; Rainer Schimpf; Eric Schulze-Bahr; Sven Zumhagen; Elijah R Behr; Rachel Bastiaenen; Jacob Tfelt-Hansen; Morten Salling Olesen; Stefan Kääb; Britt M Beckmann; Peter Weeke; Hiroshi Watanabe; Naoto Endo; Tohru Minamino; Minoru Horie; Seiko Ohno; Kanae Hasegawa; Naomasa Makita; Akihiko Nogami; Wataru Shimizu; Takeshi Aiba; Philippe Froguel; Beverley Balkau; Olivier Lantieri; Margherita Torchio; Cornelia Wiese; David Weber; Rianne Wolswinkel; Ruben Coronel; Bas J Boukens; Stéphane Bézieau; Eric Charpentier; Stéphanie Chatel; Aurore Despres; Françoise Gros; Florence Kyndt; Simon Lecointe; Pierre Lindenbaum; Vincent Portero; Jade Violleau; Manfred Gessler; Hanno L Tan; Dan M Roden; Vincent M Christoffels; Hervé Le Marec; Arthur A Wilde; Vincent Probst; Jean-Jacques Schott; Christian Dina; Richard Redon

doi:10.1038/ng.2712

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Connie Bezzina, Julien Barc, Yuka Mizusawa, Carol Ann Remme, Jean-Baptiste Gourraud, Floriane Simonet, Arie O Verkerk, Peter J Schwartz, Lia Crotti, Federica Dagradi, Pascale Guicheney, Véronique Fressart, Antoine Leenhardt, Charles Antzelevitch, Susan Bartkowiak, Martin Borggrefe, Rainer Schimpf, Eric Schulze-Bahr, Sven Zumhagen, Elijah R BehrRachel Bastiaenen, Jacob Tfelt-Hansen, Morten Salling Olesen, Stefan Kääb, Britt M Beckmann, Peter Weeke, Hiroshi Watanabe, Naoto Endo, Tohru Minamino, Minoru Horie, Seiko Ohno, Kanae Hasegawa, Naomasa Makita, Akihiko Nogami, Wataru Shimizu, Takeshi Aiba, Philippe Froguel, Beverley Balkau, Olivier Lantieri, Margherita Torchio, Cornelia Wiese, David Weber, Rianne Wolswinkel, Ruben Coronel, Bas J Boukens, Stéphane Bézieau, Eric Charpentier, Stéphanie Chatel, Aurore Despres, Françoise Gros, Florence Kyndt, Simon Lecointe, Pierre Lindenbaum, Vincent Portero, Jade Violleau, Manfred Gessler, Hanno L Tan, Dan M Roden, Vincent M Christoffels, Hervé Le Marec, Arthur A Wilde, Vincent Probst, Jean-Jacques Schott, Christian Dina, Richard Redon

Molecular Cardiology and Membrane Proteins

Research output: Contribution to journal › Letter › Research › peer-review

443 Citations (Scopus)

Original language	English
Journal	Nature Genetics
Volume	45
Issue number	9
Pages (from-to)	1044-1049
Number of pages	6
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.2712
Publication status	Published - 2013

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10.1038/ng.2712

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Bezzina, C., Barc, J., Mizusawa, Y., Remme, C. A., Gourraud, J-B., Simonet, F., Verkerk, A. O., Schwartz, P. J., Crotti, L., Dagradi, F., Guicheney, P., Fressart, V., Leenhardt, A., Antzelevitch, C., Bartkowiak, S., Borggrefe, M., Schimpf, R., Schulze-Bahr, E., Zumhagen, S., ... Redon, R. (2013). Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nature Genetics, 45(9), 1044-1049. https://doi.org/10.1038/ng.2712

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. / Bezzina, Connie; Barc, Julien; Mizusawa, Yuka; Remme, Carol Ann; Gourraud, Jean-Baptiste; Simonet, Floriane; Verkerk, Arie O; Schwartz, Peter J; Crotti, Lia; Dagradi, Federica; Guicheney, Pascale; Fressart, Véronique; Leenhardt, Antoine; Antzelevitch, Charles; Bartkowiak, Susan; Borggrefe, Martin; Schimpf, Rainer; Schulze-Bahr, Eric; Zumhagen, Sven; Behr, Elijah R; Bastiaenen, Rachel; Tfelt-Hansen, Jacob; Olesen, Morten Salling; Kääb, Stefan; Beckmann, Britt M; Weeke, Peter; Watanabe, Hiroshi; Endo, Naoto; Minamino, Tohru; Horie, Minoru; Ohno, Seiko; Hasegawa, Kanae; Makita, Naomasa; Nogami, Akihiko; Shimizu, Wataru; Aiba, Takeshi; Froguel, Philippe; Balkau, Beverley; Lantieri, Olivier; Torchio, Margherita; Wiese, Cornelia; Weber, David; Wolswinkel, Rianne; Coronel, Ruben; Boukens, Bas J; Bézieau, Stéphane; Charpentier, Eric; Chatel, Stéphanie; Despres, Aurore; Gros, Françoise; Kyndt, Florence; Lecointe, Simon; Lindenbaum, Pierre; Portero, Vincent; Violleau, Jade; Gessler, Manfred; Tan, Hanno L; Roden, Dan M; Christoffels, Vincent M; Le Marec, Hervé; Wilde, Arthur A; Probst, Vincent; Schott, Jean-Jacques; Dina, Christian; Redon, Richard.

In: Nature Genetics, Vol. 45, No. 9, 2013, p. 1044-1049.

Research output: Contribution to journal › Letter › Research › peer-review

Bezzina, C, Barc, J, Mizusawa, Y, Remme, CA, Gourraud, J-B, Simonet, F, Verkerk, AO, Schwartz, PJ, Crotti, L, Dagradi, F, Guicheney, P, Fressart, V, Leenhardt, A, Antzelevitch, C, Bartkowiak, S, Borggrefe, M, Schimpf, R, Schulze-Bahr, E, Zumhagen, S, Behr, ER, Bastiaenen, R, Tfelt-Hansen, J, Olesen, MS, Kääb, S, Beckmann, BM, Weeke, P, Watanabe, H, Endo, N, Minamino, T, Horie, M, Ohno, S, Hasegawa, K, Makita, N, Nogami, A, Shimizu, W, Aiba, T, Froguel, P, Balkau, B, Lantieri, O, Torchio, M, Wiese, C, Weber, D, Wolswinkel, R, Coronel, R, Boukens, BJ, Bézieau, S, Charpentier, E, Chatel, S, Despres, A, Gros, F, Kyndt, F, Lecointe, S, Lindenbaum, P, Portero, V, Violleau, J, Gessler, M, Tan, HL, Roden, DM, Christoffels, VM, Le Marec, H, Wilde, AA, Probst, V, Schott, J-J, Dina, C & Redon, R 2013, 'Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death', Nature Genetics, vol. 45, no. 9, pp. 1044-1049. https://doi.org/10.1038/ng.2712

Bezzina, Connie ; Barc, Julien ; Mizusawa, Yuka ; Remme, Carol Ann ; Gourraud, Jean-Baptiste ; Simonet, Floriane ; Verkerk, Arie O ; Schwartz, Peter J ; Crotti, Lia ; Dagradi, Federica ; Guicheney, Pascale ; Fressart, Véronique ; Leenhardt, Antoine ; Antzelevitch, Charles ; Bartkowiak, Susan ; Borggrefe, Martin ; Schimpf, Rainer ; Schulze-Bahr, Eric ; Zumhagen, Sven ; Behr, Elijah R ; Bastiaenen, Rachel ; Tfelt-Hansen, Jacob ; Olesen, Morten Salling ; Kääb, Stefan ; Beckmann, Britt M ; Weeke, Peter ; Watanabe, Hiroshi ; Endo, Naoto ; Minamino, Tohru ; Horie, Minoru ; Ohno, Seiko ; Hasegawa, Kanae ; Makita, Naomasa ; Nogami, Akihiko ; Shimizu, Wataru ; Aiba, Takeshi ; Froguel, Philippe ; Balkau, Beverley ; Lantieri, Olivier ; Torchio, Margherita ; Wiese, Cornelia ; Weber, David ; Wolswinkel, Rianne ; Coronel, Ruben ; Boukens, Bas J ; Bézieau, Stéphane ; Charpentier, Eric ; Chatel, Stéphanie ; Despres, Aurore ; Gros, Françoise ; Kyndt, Florence ; Lecointe, Simon ; Lindenbaum, Pierre ; Portero, Vincent ; Violleau, Jade ; Gessler, Manfred ; Tan, Hanno L ; Roden, Dan M ; Christoffels, Vincent M ; Le Marec, Hervé ; Wilde, Arthur A ; Probst, Vincent ; Schott, Jean-Jacques ; Dina, Christian ; Redon, Richard. / Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. In: Nature Genetics. 2013 ; Vol. 45, No. 9. pp. 1044-1049.

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