Concanavalin A-induced activation of lymphocytic choriomeningitis virus memory lymphocytes into specifically cytotoxic T cells

O Marker; Allan Randrup Thomsen; G T Andersen

Concanavalin A-induced activation of lymphocytic choriomeningitis virus memory lymphocytes into specifically cytotoxic T cells

O Marker, Allan Randrup Thomsen, G T Andersen

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Abstract

When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.

Original language	English
Journal	Acta pathologica et microbiologica Scandinavica. Section C, Immunology
Volume	85C
Issue number	6
Pages (from-to)	483-6
Number of pages	3
ISSN	0304-1328
Publication status	Published - 1977

Bibliographical note

Keywords: Animals; Concanavalin A; Cytotoxicity, Immunologic; Immunologic Memory; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C3H; Spleen; T-Lymphocytes

Cite this

Concanavalin A-induced activation of lymphocytic choriomeningitis virus memory lymphocytes into specifically cytotoxic T cells. / Marker, O; Thomsen, Allan Randrup; Andersen, G T.
In: Acta pathologica et microbiologica Scandinavica. Section C, Immunology, Vol. 85C, No. 6, 1977, p. 483-6.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.",

author = "O Marker and Thomsen, {Allan Randrup} and Andersen, {G T}",

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AU - Marker, O

AU - Thomsen, Allan Randrup

AU - Andersen, G T

N1 - Keywords: Animals; Concanavalin A; Cytotoxicity, Immunologic; Immunologic Memory; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C3H; Spleen; T-Lymphocytes

PY - 1977

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N2 - When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.

AB - When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.

M3 - Journal article

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JO - Acta pathologica et microbiologica Scandinavica. Section C, Immunology

JF - Acta pathologica et microbiologica Scandinavica. Section C, Immunology

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