Abstract
Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.
Original language | English |
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Journal | FEBS Letters |
Volume | 217 |
Issue number | 2 |
Pages (from-to) | 232-236 |
Number of pages | 5 |
ISSN | 0014-5793 |
Publication status | Published - 1987 |
Keywords
- Animals
- Biological Transport
- Calcium
- Cytosol
- Kinetics
- Male
- Muscle Contraction
- Muscles
- Phospholipids
- Protein Kinase C
- Rats
- Rats, Inbred Strains
- Subcellular Fractions