Contraction-associated translocation of protein kinase C in rat skeletal muscle

Erik A. Richter, P J Cleland, S Rattigan, M G Clark

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    Abstract

    Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.

    Original languageEnglish
    JournalFEBS Letters
    Volume217
    Issue number2
    Pages (from-to)232-236
    Number of pages5
    ISSN0014-5793
    Publication statusPublished - 1987

    Keywords

    • Animals
    • Biological Transport
    • Calcium
    • Cytosol
    • Kinetics
    • Male
    • Muscle Contraction
    • Muscles
    • Phospholipids
    • Protein Kinase C
    • Rats
    • Rats, Inbred Strains
    • Subcellular Fractions

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