Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity

Preet S Chadha; Thomas A Jepps; Georgina Carr; Jennifer B Stott; Hei-Lei Zhu; William C Cole; Iain A Greenwood

doi:10.1161/ATVBAHA.114.303405

Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity

Preet S Chadha, Thomas A Jepps, Georgina Carr, Jennifer B Stott, Hei-Lei Zhu, William C Cole, Iain A Greenwood

Physiology of circulation, kidney and lung

Research output: Contribution to journal › Journal article › Research › peer-review

74 Citations (Scopus)

Abstract

Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals.

Original language	English
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	34
Issue number	4
Pages (from-to)	887-93
Number of pages	7
ISSN	1079-5642
DOIs	https://doi.org/10.1161/ATVBAHA.114.303405
Publication status	Published - Apr 2014

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10.1161/ATVBAHA.114.303405

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Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity. / Chadha, Preet S; Jepps, Thomas A; Carr, Georgina; Stott, Jennifer B; Zhu, Hei-Lei; Cole, William C; Greenwood, Iain A.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 34, No. 4, 04.2014, p. 887-93.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Carr, Georgina

AU - Stott, Jennifer B

AU - Zhu, Hei-Lei

AU - Cole, William C

AU - Greenwood, Iain A

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AB - Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals.

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DO - 10.1161/ATVBAHA.114.303405

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