Crystallization of Piroxicam Solid Forms and the Effects of Additives

Guangpu Liu; Thomas B. Hansen; Haiyan Qu; Mingshi Yang; Jari P. Pajander; Jukka Rantanen; Lars P. Christensen

doi:10.1002/ceat.201400206

Crystallization of Piroxicam Solid Forms and the Effects of Additives

Guangpu Liu, Thomas B. Hansen, Haiyan Qu^*, Mingshi Yang, Jari P. Pajander, Jukka Rantanen, Lars P. Christensen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Abstract

The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δ_T and the hydrogen bonding solubility parameter δ_H of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δ_T and δ_H parameters similar to those of piroxicam.

Original language	English
Journal	Chemical Engineering and Technology
Volume	37
Issue number	8
Pages (from-to)	1297-1304
Number of pages	8
ISSN	0930-7516
DOIs	https://doi.org/10.1002/ceat.201400206
Publication status	Published - 2014

Keywords

Crystallization
Effect of additives
Monohydrate
Pharmaceutical products
Polymorphism
Relative thermodynamic stability

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10.1002/ceat.201400206

Cite this

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title = "Crystallization of Piroxicam Solid Forms and the Effects of Additives",

abstract = "The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.",

keywords = "Crystallization, Effect of additives, Monohydrate, Pharmaceutical products, Polymorphism, Relative thermodynamic stability",

author = "Guangpu Liu and Hansen, {Thomas B.} and Haiyan Qu and Mingshi Yang and Pajander, {Jari P.} and Jukka Rantanen and Christensen, {Lars P.}",

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T1 - Crystallization of Piroxicam Solid Forms and the Effects of Additives

AU - Liu, Guangpu

AU - Hansen, Thomas B.

AU - Qu, Haiyan

AU - Yang, Mingshi

AU - Pajander, Jari P.

AU - Rantanen, Jukka

AU - Christensen, Lars P.

PY - 2014

Y1 - 2014

N2 - The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.

AB - The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.

KW - Crystallization

KW - Effect of additives

KW - Monohydrate

KW - Pharmaceutical products

KW - Polymorphism

KW - Relative thermodynamic stability

U2 - 10.1002/ceat.201400206

DO - 10.1002/ceat.201400206

M3 - Journal article

AN - SCOPUS:84904806350

VL - 37

SP - 1297

EP - 1304

JO - Chemical Engineering and Technology

JF - Chemical Engineering and Technology

SN - 0930-7516

IS - 8

ER -