Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

Jennifer van der Horst, Iain A. Greenwood, Thomas A. Jepps*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

33 Citations (Scopus)
95 Downloads (Pure)

Abstract

Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.

Original languageEnglish
Article number727
JournalFrontiers in Physiology
Volume11
Number of pages12
ISSN1664-042X
DOIs
Publication statusPublished - 2020

Keywords

  • cAMP
  • EPAC
  • Kv7 (KCNQ)
  • physiology
  • PKA

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