D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria: a focused review

Misbah Noshela Ghazanfar, Simon Francis Thomsen

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14 Citations (Scopus)

Abstract

Chronic urticaria is an itchy skin disease, which is treated with antihistamines; however, a large group of patients are unresponsive to antihistamines alone and are thus treated with omalizumab, although a small fraction of these patients have particularly recalcitrant disease. Currently, there are no reliable biomarkers available to assess disease activity/severity and treatment response in chronic urticaria patients. However, it has been reported that high levels of d-dimer are observed during disease activity and are significantly reduced during periods of remission. We present a focused overview of studies investigating plasma d-dimer level as a biomarker for disease activity and treatment response in patients with chronic urticaria.
Original languageEnglish
JournalEuropean Journal of Dermatology
Volume28
Issue number6
Pages (from-to)731-735
ISSN1167-1122
DOIs
Publication statusPublished - 2018

Keywords

  • chronic urticaria
  • D-dimer
  • biomarker
  • disease activity
  • treatment response

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