Days alive and out of hospital following transoral robotic surgery: Cohort study of 262 patients with head and neck cancer

Mikkel H.H. Larsen*, Susanne I. Scott, Hani I. Channir, Anne K.Ø. Madsen, Birgitte W. Charabi, Niclas Rubek, Jesper F. Tvedskov, Henrik Kehlet, Christian von Buchwald

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

4 Citations (Scopus)

Abstract

Background: Days alive and out of hospital (DAOH) is a validated outcome in clinical trials, since it reflects procedure-associated morbidity and mortality. Transoral robotic surgery (TORS) has become a widely adopted procedure with increasing demand for knowledge and data on morbidity. Methods: Retrospective single-center assessment of a prospective TORS database comprising patients treated for malignancy between 2013 and 2018 using DAOH to describe procedure- and disease-related morbidity the first 12-postoperative months. Results: For 262 patients, median DAOH365 was 357 days (IQR 351–360). Indications for TORS were (i) primary curative resection (61%), (ii) salvage resection (15%), and (iii) diagnostic work-up of cancer of unknown primary in the head and neck (24%). Median DAOH365 was 359 days (IQR 351–361 days), 348 days (IQR 233–355), and 357 days (351–361), respectively. Pneumonia had the highest impact in DAOH365 reduction. Conclusion: Total median DAOH365 after TORS was 357 days. The main cause leading to DAOH365 reduction was pneumonia.

Original languageEnglish
JournalHead and Neck
Volume43
Issue number12
Pages (from-to)3866-3874
ISSN1043-3074
DOIs
Publication statusPublished - 2021

Bibliographical note

Funding Information:
Candys Foundation, Grant/Award Number: 2019-304; Doctor Fritz Karner and Wife's Foundation; Region Hovedstaden, Grant/Award Number: A6682

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

Keywords

  • cancer
  • morbidity
  • perioperative medicine
  • postoperative outcomes
  • surgery

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