Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.

Eva Julià, Xavier Montalban, Hammad Al-Zayat, Shohreh Issazadeh-Navikas, Robert Goertsches, Roland Martin, Manuel Comabella

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    16 Citations (Scopus)

    Abstract

    OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
    Original languageEnglish
    JournalJournal of Neuroimmunology
    Volume180
    Issue number1-2
    Pages (from-to)147-58
    Number of pages11
    ISSN0165-5728
    DOIs
    Publication statusPublished - 2006

    Bibliographical note

    Keywords: Adult; Aged; Antigens, CD; Antigens, CD95; Antigens, Differentiation, T-Lymphocyte; Apoptosis; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Survival; Chemotaxis, Leukocyte; Down-Regulation; Fas Ligand Protein; Female; Humans; Immunity, Cellular; Male; Middle Aged; Multiple Sclerosis; Proto-Oncogene Proteins c-bcl-2; Receptors, CCR5; TNF Receptor-Associated Death Domain Protein; bcl-2-Associated X Protein

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