Abstract
Bedside diagnosis of skin cancer remains a challenging task. The real-time noninvasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results.
Original language | English |
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Article number | e202100083 |
Journal | journal of biophotonics |
Volume | 14 |
Issue number | 11 |
Number of pages | 9 |
ISSN | 1864-063X |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Funding Information:We acknowledge support from Innovation Fund Denmark under the project J. No. 4107‐00011A (ShapeOCT), Vissing Foundation, Denmark and the Research Foundation of Bispebjerg and Frederiksberg Hospital financing part of Mette Mogensen's salary.
Publisher Copyright:
© 2021 Wiley-VCH GmbH
Keywords
- angiography
- basal cell carcinoma
- BCC
- OCT
- optical coherence tomography
- papillary dermis
- ultrahigh resolution
- upper dermis