Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study

Patrick Rossignol; John G F Cleland; Sunil Bhandari; Stéphane Tala; Finn Gustafsson; Renaud Fay; Zohra Lamiral; Daniela Dobre; Bertram Pitt; Faiez Zannad

doi:10.1161/CIRCULATIONAHA.111.028282

Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study

Patrick Rossignol, John G F Cleland, Sunil Bhandari, Stéphane Tala, Finn Gustafsson, Renaud Fay, Zohra Lamiral, Daniela Dobre, Bertram Pitt, Faiez Zannad

Research output: Contribution to journal › Journal article › Research › peer-review

145 Citations (Scopus)

Abstract

We evaluated the effect of the selective mineralocorticoid receptor antagonist eplerenone on renal function and the interaction between changes in renal function and subsequent cardiovascular outcomes in patients with heart failure and left ventricular systolic dysfunction after an acute myocardial infarction in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS).

Original language	English
Journal	Circulation
Volume	125
Issue number	2
Pages (from-to)	271-9
Number of pages	9
ISSN	0009-7322
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.111.028282
Publication status	Published - 2012

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Rossignol, P., Cleland, J. G. F., Bhandari, S., Tala, S., Gustafsson, F., Fay, R., Lamiral, Z., Dobre, D., Pitt, B., & Zannad, F. (2012). Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study. Circulation, 125(2), 271-9. https://doi.org/10.1161/CIRCULATIONAHA.111.028282

Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study. / Rossignol, Patrick; Cleland, John G F; Bhandari, Sunil et al.
In: Circulation, Vol. 125, No. 2, 2012, p. 271-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Rossignol, P, Cleland, JGF, Bhandari, S, Tala, S, Gustafsson, F, Fay, R, Lamiral, Z, Dobre, D, Pitt, B & Zannad, F 2012, 'Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study', Circulation, vol. 125, no. 2, pp. 271-9. https://doi.org/10.1161/CIRCULATIONAHA.111.028282

Rossignol P, Cleland JGF, Bhandari S, Tala S, Gustafsson F, Fay R et al. Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study. Circulation. 2012;125(2):271-9. doi: 10.1161/CIRCULATIONAHA.111.028282

Rossignol, Patrick ; Cleland, John G F ; Bhandari, Sunil et al. / Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction : insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study. In: Circulation. 2012 ; Vol. 125, No. 2. pp. 271-9.

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