TY - JOUR
T1 - Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
AU - Karl, Maximilian
AU - Rantanen, Jukka
AU - Rades, Thomas
PY - 2019/12/6
Y1 - 2019/12/6
N2 - Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.
AB - Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.
U2 - 10.3390/pharmaceutics11120670
DO - 10.3390/pharmaceutics11120670
M3 - Journal article
C2 - 31835607
VL - 11
JO - Pharmaceutics
JF - Pharmaceutics
SN - 1999-4923
IS - 12
M1 - 670
ER -