TY - JOUR
T1 - Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels
AU - Krzystanek, Katarzyna
AU - Rasmussen, Hanne Borger
AU - Grunnet, Morten
AU - Staub, Olivier
AU - Olesen, Søren-Peter
AU - Abriel, Hugues
AU - Jespersen, Thomas
N1 - Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
PY - 2012
Y1 - 2012
N2 - KCNQ1 (Kv7.1), together with its KCNE ß subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes. Nedd4/Nedd4-like (neuronal precursor cell-expressed developmentally downregulated 4) ubiquitin-protein ligases interact with the KCNQ1 potassium channel through a PY motif located in the C terminus of KCNQ1. This interaction induces ubiquitylation of KCNQ1, resulting in a reduced surface density of the channel. It was reported recently that the epithelial sodium channel is regulated by the reverse process-deubiquitylation-mediated by USP2 (ubiquitin-specific protease 2).
AB - KCNQ1 (Kv7.1), together with its KCNE ß subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes. Nedd4/Nedd4-like (neuronal precursor cell-expressed developmentally downregulated 4) ubiquitin-protein ligases interact with the KCNQ1 potassium channel through a PY motif located in the C terminus of KCNQ1. This interaction induces ubiquitylation of KCNQ1, resulting in a reduced surface density of the channel. It was reported recently that the epithelial sodium channel is regulated by the reverse process-deubiquitylation-mediated by USP2 (ubiquitin-specific protease 2).
U2 - 10.1016/j.hrthm.2011.10.026
DO - 10.1016/j.hrthm.2011.10.026
M3 - Journal article
C2 - 22024150
VL - 9
SP - 440
EP - 448
JO - Heart Rhythm
JF - Heart Rhythm
SN - 1547-5271
IS - 3
ER -