Development and descent of the testis in relation to cryptorchidism

Helena E Virtanen; Dina Cortes; Ewa Rajpert-De Meyts; E Martin Ritzén; Agneta Nordenskjöld; Niels E Skakkebaek; Jorma Toppari

doi:10.1111/j.1651-2227.2007.00244.x

Development and descent of the testis in relation to cryptorchidism

Helena E Virtanen, Dina Cortes, Ewa Rajpert-De Meyts, E Martin Ritzén, Agneta Nordenskjöld, Niels E Skakkebaek, Jorma Toppari

Department of Clinical Medicine

Research output: Contribution to journal › Journal article › Research › peer-review

88 Citations (Scopus)

Abstract

The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.

Original language	English
Journal	Acta Paediatrica
Volume	96
Issue number	5
Pages (from-to)	622-7
Number of pages	6
ISSN	0803-5253
DOIs	https://doi.org/10.1111/j.1651-2227.2007.00244.x
Publication status	Published - 1 May 2007

Keywords

Animals
Cell Differentiation
Child
Cryptorchidism
Humans
Infant
Insulin
Leydig Cells
Male
Models, Animal
Proteins
Testis

Access to Document

10.1111/j.1651-2227.2007.00244.x

Library access?

Check availability at the Royal Danish Library

Cite this

@article{a12f393f4593412ba6d4f49b843189bc,

title = "Development and descent of the testis in relation to cryptorchidism",

abstract = "The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.",

keywords = "Animals, Cell Differentiation, Child, Cryptorchidism, Humans, Infant, Insulin, Leydig Cells, Male, Models, Animal, Proteins, Testis",

author = "Virtanen, {Helena E} and Dina Cortes and {Rajpert-De Meyts}, Ewa and Ritz{\'e}n, {E Martin} and Agneta Nordenskj{\"o}ld and Skakkebaek, {Niels E} and Jorma Toppari",

year = "2007",

month = may,

day = "1",

doi = "10.1111/j.1651-2227.2007.00244.x",

language = "English",

volume = "96",

pages = "622--7",

journal = "Acta Paediatrica",

issn = "0803-5253",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Development and descent of the testis in relation to cryptorchidism

AU - Virtanen, Helena E

AU - Cortes, Dina

AU - Rajpert-De Meyts, Ewa

AU - Ritzén, E Martin

AU - Nordenskjöld, Agneta

AU - Skakkebaek, Niels E

AU - Toppari, Jorma

PY - 2007/5/1

Y1 - 2007/5/1

N2 - The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.

AB - The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.

KW - Animals

KW - Cell Differentiation

KW - Child

KW - Cryptorchidism

KW - Humans

KW - Infant

KW - Insulin

KW - Leydig Cells

KW - Male

KW - Models, Animal

KW - Proteins

KW - Testis

U2 - 10.1111/j.1651-2227.2007.00244.x

DO - 10.1111/j.1651-2227.2007.00244.x

M3 - Journal article

C2 - 17462055

SN - 0803-5253

VL - 96

SP - 622

EP - 627

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 5

ER -