Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Matthias Manfred Herth; Valdemar L.  Andersen; Szabolcs Lehel; Jacob Madsen; Gitte Moos Knudsen; Jesper Langgaard Kristensen

doi:10.1039/C3CC41027G

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Matthias Manfred Herth, Valdemar L. Andersen, Szabolcs Lehel, Jacob Madsen, Gitte Moos Knudsen, Jesper Langgaard Kristensen

Research output: Contribution to journal › Journal article › Research › peer-review

63 Citations (Scopus)

Abstract

Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

Original language	English
Journal	Chemical Communications
Volume	49
Pages (from-to)	3805-3807
Number of pages	3
ISSN	1359-7345
DOIs	https://doi.org/10.1039/C3CC41027G
Publication status	Published - 2013

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10.1039/C3CC41027G

Cite this

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title = "Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation",

abstract = "Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.",

author = "Herth, {Matthias Manfred} and Andersen, {Valdemar L.} and Szabolcs Lehel and Jacob Madsen and Knudsen, {Gitte Moos} and Kristensen, {Jesper Langgaard}",

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volume = "49",

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journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

AU - Herth, Matthias Manfred

AU - Andersen, Valdemar L.

AU - Lehel, Szabolcs

AU - Madsen, Jacob

AU - Knudsen, Gitte Moos

AU - Kristensen, Jesper Langgaard

PY - 2013

Y1 - 2013

N2 - Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

AB - Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

U2 - 10.1039/C3CC41027G

DO - 10.1039/C3CC41027G

M3 - Journal article

SN - 1359-7345

VL - 49

SP - 3805

EP - 3807

JO - Chemical Communications

JF - Chemical Communications

ER -