Abstract
Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) - one of the most prominent members of this intriguing family of natural products. 1 Introduction 2 Synthetic Strategy 2.1 First Generation 2.2 Second Generation 2.3 Third Generation 2.3.1 Radical Endgame 2.3.2 Completion of the Total Synthesis 3 Conclusion.
Original language | English |
---|---|
Article number | st-2019-a0679-a |
Journal | Synlett |
Volume | 31 |
Issue number | 4 |
Pages (from-to) | 327-333 |
Number of pages | 7 |
ISSN | 0936-5214 |
DOIs | |
Publication status | Published - 3 Mar 2020 |
Keywords
- asymmetric allylic alkylation
- decarboxylative cross coupling
- Erythrina alkaloids
- ring closing metathesis
- spiroamine
- total synthesis