Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial

Anders Granholm; Marie Warrer Munch; Sheila Nainan Myatra; Bharath Kumar Tirupakuzhi Vijayaraghavan; Maria Cronhjort; Rebecka Rubenson Wahlin; Stephan M. Jakob; Luca Cioccari; Maj-Brit Norregaard Kjaer; Gitte Kingo Vesterlund; Tine Sylvest Meyhoff; Marie Helleberg; Morten Hylander Moller; Thomas Benfield; Balasubramanian Venkatesh; Naomi E. Hammond; Sharon Micallef; Abhinav Bassi; Oommen John; Vivekanand Jha; Klaus Tjelle Kristiansen; Charlotte Suppli Ulrik; Vibeke Lind Jorgensen; Margit Smitt; Morten H. Bestle; Anne Sofie Andreasen; Lone Musaeus Poulsen; Bodil Steen Rasmussen; Anne Craveiro Brochner; Thomas Strom; Anders Moller; Mohd Saif Khan; Ajay Padmanaban; Jigeeshu Vasishtha Divatia; Sanjith Saseedharan; Kapil Borawake; Farhad Kapadia; Subhal Dixit; Rajesh Chawla; Urvi Shukla; Pravin Amin; Michelle S. Chew; Christian Aage Wamberg; Christian Gluud; Theis Lange; Anders Perner

doi:10.1007/s00134-021-06573-1

Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial

Anders Granholm, Marie Warrer Munch, Sheila Nainan Myatra, Bharath Kumar Tirupakuzhi Vijayaraghavan, Maria Cronhjort, Rebecka Rubenson Wahlin, Stephan M. Jakob, Luca Cioccari, Maj-Brit Norregaard Kjaer, Gitte Kingo Vesterlund, Tine Sylvest Meyhoff, Marie Helleberg, Morten Hylander Moller, Thomas Benfield, Balasubramanian Venkatesh, Naomi E. Hammond, Sharon Micallef, Abhinav Bassi, Oommen John, Vivekanand JhaKlaus Tjelle Kristiansen, Charlotte Suppli Ulrik, Vibeke Lind Jorgensen, Margit Smitt, Morten H. Bestle, Anne Sofie Andreasen, Lone Musaeus Poulsen, Bodil Steen Rasmussen, Anne Craveiro Brochner, Thomas Strom, Anders Moller, Mohd Saif Khan, Ajay Padmanaban, Jigeeshu Vasishtha Divatia, Sanjith Saseedharan, Kapil Borawake, Farhad Kapadia, Subhal Dixit, Rajesh Chawla, Urvi Shukla, Pravin Amin, Michelle S. Chew, Christian Aage Wamberg, Christian Gluud, Theis Lange, Anders Perner

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

Original language	English
Journal	Intensive Care Medicine
Volume	48
Pages (from-to)	45–55
Number of pages	11
ISSN	0342-4642
DOIs	https://doi.org/10.1007/s00134-021-06573-1
Publication status	Published - 2022

Keywords

COVID-19
Hypoxaemia
Critical illness
Corticosteroids
Bayesian analysis

Access to Document

10.1007/s00134-021-06573-1

https://europepmc.org/articles/pmc8579417?pdf=renderLicence: Other

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Cite this

Granholm, A., Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Kjaer, M.-B. N., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Moller, M. H., Benfield, T., Venkatesh, B., Hammond, N. E., Micallef, S., Bassi, A., John, O., ... Perner, A. (2022). Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial. Intensive Care Medicine, 48, 45–55. https://doi.org/10.1007/s00134-021-06573-1

Granholm, A, Munch, MW, Myatra, SN, Vijayaraghavan, BKT, Cronhjort, M, Wahlin, RR, Jakob, SM, Cioccari, L, Kjaer, M-BN, Vesterlund, GK, Meyhoff, TS, Helleberg, M, Moller, MH , Benfield, T, Venkatesh, B, Hammond, NE, Micallef, S, Bassi, A, John, O, Jha, V, Kristiansen, KT , Ulrik, CS, Jorgensen, VL, Smitt, M, Bestle, MH , Andreasen, AS, Poulsen, LM, Rasmussen, BS, Brochner, AC, Strom, T, Moller, A, Khan, MS, Padmanaban, A, Divatia, JV, Saseedharan, S, Borawake, K, Kapadia, F, Dixit, S, Chawla, R, Shukla, U, Amin, P, Chew, MS, Wamberg, CA, Gluud, C, Lange, T & Perner, A 2022, 'Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial', Intensive Care Medicine, vol. 48, pp. 45–55. https://doi.org/10.1007/s00134-021-06573-1

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T2 - a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial

AU - Granholm, Anders

AU - Munch, Marie Warrer

AU - Myatra, Sheila Nainan

AU - Vijayaraghavan, Bharath Kumar Tirupakuzhi

AU - Cronhjort, Maria

AU - Wahlin, Rebecka Rubenson

AU - Jakob, Stephan M.

AU - Cioccari, Luca

AU - Kjaer, Maj-Brit Norregaard

AU - Vesterlund, Gitte Kingo

AU - Meyhoff, Tine Sylvest

AU - Helleberg, Marie

AU - Moller, Morten Hylander

AU - Benfield, Thomas

AU - Venkatesh, Balasubramanian

AU - Hammond, Naomi E.

AU - Micallef, Sharon

AU - Bassi, Abhinav

AU - John, Oommen

AU - Jha, Vivekanand

AU - Kristiansen, Klaus Tjelle

AU - Ulrik, Charlotte Suppli

AU - Jorgensen, Vibeke Lind

AU - Smitt, Margit

AU - Bestle, Morten H.

AU - Andreasen, Anne Sofie

AU - Poulsen, Lone Musaeus

AU - Rasmussen, Bodil Steen

AU - Brochner, Anne Craveiro

AU - Strom, Thomas

AU - Moller, Anders

AU - Khan, Mohd Saif

AU - Padmanaban, Ajay

AU - Divatia, Jigeeshu Vasishtha

AU - Saseedharan, Sanjith

AU - Borawake, Kapil

AU - Kapadia, Farhad

AU - Dixit, Subhal

AU - Chawla, Rajesh

AU - Shukla, Urvi

AU - Amin, Pravin

AU - Chew, Michelle S.

AU - Wamberg, Christian Aage

AU - Gluud, Christian

AU - Lange, Theis

AU - Perner, Anders

PY - 2022

Y1 - 2022

KW - COVID-19

KW - Hypoxaemia

KW - Critical illness

KW - Corticosteroids

KW - Bayesian analysis

U2 - 10.1007/s00134-021-06573-1

DO - 10.1007/s00134-021-06573-1

M3 - Journal article

C2 - 34757439

SN - 0342-4642

VL - 48

SP - 45

EP - 55

JO - Intensive Care Medicine

JF - Intensive Care Medicine

ER -