Abstract
There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups.
| Original language | English |
|---|---|
| Journal | The Lancet Neurology |
| Volume | 21 |
| Issue number | 12 |
| Pages (from-to) | 1120-1134 |
| Number of pages | 15 |
| ISSN | 1474-4422 |
| DOIs | |
| Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:© 2022 Elsevier Ltd
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Diagnosis and classification of optic neuritis. / Petzold, Axel; Fraser, Clare L.; Abegg, Mathias; Alroughani, Raed; Alshowaeir, Daniah; Alvarenga, Regina; Andris, Cécile; Asgari, Nasrin; Barnett, Yael; Battistella, Roberto; Behbehani, Raed; Berger, Thomas; Bikbov, Mukharram M.; Biotti, Damien; Biousse, Valerie; Boschi, Antonella; Brazdil, Milan; Brezhnev, Andrei; Calabresi, Peter A.; Cordonnier, Monique; Costello, Fiona; Cruz, Franz M.; Cunha, Leonardo Provetti; Daoudi, Smail; Deschamps, Romain; de Seze, Jerome; Diem, Ricarda; Etemadifar, Masoud; Flores-Rivera, Jose; Fonseca, Pedro; Frederiksen, Jette; Frohman, Elliot; Frohman, Teresa; Tilikete, Caroline Froment; Fujihara, Kazuo; Gálvez, Alberto; Gouider, Riadh; Gracia, Fernando; Grigoriadis, Nikolaos; Guajardo, José M.; Habek, Mario; Hawlina, Marko; Martínez-Lapiscina, Elena H.; Hooker, Juzar; Hor, Jyh Yung; Howlett, William; Huang-Link, Yumin; Idrissova, Zhannat; Illes, Zsolt; Jancic, Jasna; Jindahra, Panitha; Karussis, Dimitrios; Kerty, Emilia; Kim, Ho Jin; Lagrèze, Wolf; Leocani, Letizia; Levin, Netta; Liskova, Petra; Liu, Yaou; Maiga, Youssoufa; Marignier, Romain; McGuigan, Chris; Meira, Dália; Merle, Harold; Monteiro, Mário L.R.; Moodley, Anand; Moura, Frederico; Muñoz, Silvia; Mustafa, Sharik; Nakashima, Ichiro; Noval, Susana; Oehninger, Carlos; Ogun, Olufunmilola; Omoti, Afekhide; Pandit, Lekha; Paul, Friedemann; Rebolleda, Gema; Reddel, Stephen; Rejdak, Konrad; Rejdak, Robert; Rodriguez-Morales, Alfonso J.; Rougier, Marie Bénédicte; Sa, Maria Jose; Sanchez-Dalmau, Bernardo; Saylor, Deanna; Shatriah, Ismail; Siva, Aksel; Stiebel-Kalish, Hadas; Szatmary, Gabriella; Ta, Linh; Tenembaum, Silvia; Tran, Huy; Trufanov, Yevgen; van Pesch, Vincent; Wang, An Guor; Wattjes, Mike P.; Willoughby, Ernest; Zakaria, Magd; Zvornicanin, Jasmin; Balcer, Laura; Plant, Gordon T.
In: The Lancet Neurology, Vol. 21, No. 12, 2022, p. 1120-1134.Research output: Contribution to journal › Review › Research › peer-review
}
TY - JOUR
T1 - Diagnosis and classification of optic neuritis
AU - Petzold, Axel
AU - Fraser, Clare L.
AU - Abegg, Mathias
AU - Alroughani, Raed
AU - Alshowaeir, Daniah
AU - Alvarenga, Regina
AU - Andris, Cécile
AU - Asgari, Nasrin
AU - Barnett, Yael
AU - Battistella, Roberto
AU - Behbehani, Raed
AU - Berger, Thomas
AU - Bikbov, Mukharram M.
AU - Biotti, Damien
AU - Biousse, Valerie
AU - Boschi, Antonella
AU - Brazdil, Milan
AU - Brezhnev, Andrei
AU - Calabresi, Peter A.
AU - Cordonnier, Monique
AU - Costello, Fiona
AU - Cruz, Franz M.
AU - Cunha, Leonardo Provetti
AU - Daoudi, Smail
AU - Deschamps, Romain
AU - de Seze, Jerome
AU - Diem, Ricarda
AU - Etemadifar, Masoud
AU - Flores-Rivera, Jose
AU - Fonseca, Pedro
AU - Frederiksen, Jette
AU - Frohman, Elliot
AU - Frohman, Teresa
AU - Tilikete, Caroline Froment
AU - Fujihara, Kazuo
AU - Gálvez, Alberto
AU - Gouider, Riadh
AU - Gracia, Fernando
AU - Grigoriadis, Nikolaos
AU - Guajardo, José M.
AU - Habek, Mario
AU - Hawlina, Marko
AU - Martínez-Lapiscina, Elena H.
AU - Hooker, Juzar
AU - Hor, Jyh Yung
AU - Howlett, William
AU - Huang-Link, Yumin
AU - Idrissova, Zhannat
AU - Illes, Zsolt
AU - Jancic, Jasna
AU - Jindahra, Panitha
AU - Karussis, Dimitrios
AU - Kerty, Emilia
AU - Kim, Ho Jin
AU - Lagrèze, Wolf
AU - Leocani, Letizia
AU - Levin, Netta
AU - Liskova, Petra
AU - Liu, Yaou
AU - Maiga, Youssoufa
AU - Marignier, Romain
AU - McGuigan, Chris
AU - Meira, Dália
AU - Merle, Harold
AU - Monteiro, Mário L.R.
AU - Moodley, Anand
AU - Moura, Frederico
AU - Muñoz, Silvia
AU - Mustafa, Sharik
AU - Nakashima, Ichiro
AU - Noval, Susana
AU - Oehninger, Carlos
AU - Ogun, Olufunmilola
AU - Omoti, Afekhide
AU - Pandit, Lekha
AU - Paul, Friedemann
AU - Rebolleda, Gema
AU - Reddel, Stephen
AU - Rejdak, Konrad
AU - Rejdak, Robert
AU - Rodriguez-Morales, Alfonso J.
AU - Rougier, Marie Bénédicte
AU - Sa, Maria Jose
AU - Sanchez-Dalmau, Bernardo
AU - Saylor, Deanna
AU - Shatriah, Ismail
AU - Siva, Aksel
AU - Stiebel-Kalish, Hadas
AU - Szatmary, Gabriella
AU - Ta, Linh
AU - Tenembaum, Silvia
AU - Tran, Huy
AU - Trufanov, Yevgen
AU - van Pesch, Vincent
AU - Wang, An Guor
AU - Wattjes, Mike P.
AU - Willoughby, Ernest
AU - Zakaria, Magd
AU - Zvornicanin, Jasmin
AU - Balcer, Laura
AU - Plant, Gordon T.
N1 - Publisher Copyright: © 2022 Elsevier Ltd
PY - 2022
Y1 - 2022
N2 - There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups.
AB - There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups.
U2 - 10.1016/S1474-4422(22)00200-9
DO - 10.1016/S1474-4422(22)00200-9
M3 - Review
C2 - 36179757
AN - SCOPUS:85141992725
VL - 21
SP - 1120
EP - 1134
JO - The Lancet Neurology
JF - The Lancet Neurology
SN - 1474-4422
IS - 12
ER -