Diagnostic accuracy of expeditious bedside evaluation of cutaneous malignant melanoma using photoacoustic imaging

Terese von Knorring; Paul Blanche; Helle Holstad Pedersen; Lisbet Rosenkrantz Hölmich; Nina Løth Mårtensson; Charlène Reichl; Katrine Karmisholt; Mette Mogensen

doi:10.1111/jdv.20046

Diagnostic accuracy of expeditious bedside evaluation of cutaneous malignant melanoma using photoacoustic imaging

Terese von Knorring^*, Paul Blanche, Helle Holstad Pedersen, Lisbet Rosenkrantz Hölmich, Nina Løth Mårtensson, Charlène Reichl, Katrine Karmisholt, Mette Mogensen

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

We study photoacoustic imaging (PAI) for diagnosing pigmented skin lesions. Clinical examination of nevi is challenging, leading to unnecessary skin biopsies. While dermoscopy improves accuracy, false positives remain high.1 PAI combines optical and ultrasound imaging by providing 3D images that visualize endogenous chromophores as melanin, haemoglobin, collagen and lipids at centimetre-depth.2-4 Reflectance confocal microscopy (RCM) offers in vivo cellular-level resolution improving diagnostic accuracy and demonstrating a 40% reduction in nevi excisions.5 By incorporating PAI alongside established methods, we aim to improve diagnostic precision.

Original language	English
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	39
Issue number	1
Pages (from-to)	e23-e25
Number of pages	3
ISSN	0926-9959
DOIs	https://doi.org/10.1111/jdv.20046
Publication status	Published - 2025

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von Knorring, T., Blanche, P., Holstad Pedersen, H., Rosenkrantz Hölmich, L., Løth Mårtensson, N., Reichl, C., Karmisholt, K., & Mogensen, M. (2025). Diagnostic accuracy of expeditious bedside evaluation of cutaneous malignant melanoma using photoacoustic imaging. Journal of the European Academy of Dermatology and Venereology, 39(1), e23-e25. https://doi.org/10.1111/jdv.20046

von Knorring, T, Blanche, P, Holstad Pedersen, H, Rosenkrantz Hölmich, L, Løth Mårtensson, N, Reichl, C, Karmisholt, K & Mogensen, M 2025, 'Diagnostic accuracy of expeditious bedside evaluation of cutaneous malignant melanoma using photoacoustic imaging', Journal of the European Academy of Dermatology and Venereology, vol. 39, no. 1, pp. e23-e25. https://doi.org/10.1111/jdv.20046

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title = "Diagnostic accuracy of expeditious bedside evaluation of cutaneous malignant melanoma using photoacoustic imaging",

abstract = "We study photoacoustic imaging (PAI) for diagnosing pigmented skin lesions. Clinical examination of nevi is challenging, leading to unnecessary skin biopsies. While dermoscopy improves accuracy, false positives remain high.1 PAI combines optical and ultrasound imaging by providing 3D images that visualize endogenous chromophores as melanin, haemoglobin, collagen and lipids at centimetre-depth.2-4 Reflectance confocal microscopy (RCM) offers in vivo cellular-level resolution improving diagnostic accuracy and demonstrating a 40% reduction in nevi excisions.5 By incorporating PAI alongside established methods, we aim to improve diagnostic precision.",

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note = "Funding Information: This study was funded by unrestricted grants from Vissing foundation, Axel Muusfeldt foundation, Toyota Foundation Denmark, Arvid Nilsson's foundation, NEYE foundation, Aase and Ejnar Danielsens foundation, Koebmand Sven Hansen & Hustru Ina Hansen's foundation and The Danish Cancer Society. ",

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T1 - Diagnostic accuracy of expeditious bedside evaluation of cutaneous malignant melanoma using photoacoustic imaging

AU - von Knorring, Terese

AU - Blanche, Paul

AU - Holstad Pedersen, Helle

AU - Rosenkrantz Hölmich, Lisbet

AU - Løth Mårtensson, Nina

AU - Reichl, Charlène

AU - Karmisholt, Katrine

AU - Mogensen, Mette

N1 - Funding Information: This study was funded by unrestricted grants from Vissing foundation, Axel Muusfeldt foundation, Toyota Foundation Denmark, Arvid Nilsson's foundation, NEYE foundation, Aase and Ejnar Danielsens foundation, Koebmand Sven Hansen & Hustru Ina Hansen's foundation and The Danish Cancer Society.

PY - 2025

Y1 - 2025

N2 - We study photoacoustic imaging (PAI) for diagnosing pigmented skin lesions. Clinical examination of nevi is challenging, leading to unnecessary skin biopsies. While dermoscopy improves accuracy, false positives remain high.1 PAI combines optical and ultrasound imaging by providing 3D images that visualize endogenous chromophores as melanin, haemoglobin, collagen and lipids at centimetre-depth.2-4 Reflectance confocal microscopy (RCM) offers in vivo cellular-level resolution improving diagnostic accuracy and demonstrating a 40% reduction in nevi excisions.5 By incorporating PAI alongside established methods, we aim to improve diagnostic precision.

AB - We study photoacoustic imaging (PAI) for diagnosing pigmented skin lesions. Clinical examination of nevi is challenging, leading to unnecessary skin biopsies. While dermoscopy improves accuracy, false positives remain high.1 PAI combines optical and ultrasound imaging by providing 3D images that visualize endogenous chromophores as melanin, haemoglobin, collagen and lipids at centimetre-depth.2-4 Reflectance confocal microscopy (RCM) offers in vivo cellular-level resolution improving diagnostic accuracy and demonstrating a 40% reduction in nevi excisions.5 By incorporating PAI alongside established methods, we aim to improve diagnostic precision.

U2 - 10.1111/jdv.20046

DO - 10.1111/jdv.20046

M3 - Letter

C2 - 38695655

AN - SCOPUS:85192158670

SN - 0926-9959

VL - 39

SP - e23-e25

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

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