Did circular DNA shape the evolution of mammalian genomes?

Sylvester Holt; Gerard Arrey; Birgitte Regenberg

doi:10.1016/j.tibs.2022.09.010

Did circular DNA shape the evolution of mammalian genomes?

Sylvester Holt, Gerard Arrey, Birgitte Regenberg^*

^*Corresponding author for this work

Ecology and Evolution

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Abstract

Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.

Original language	English
Journal	Trends in Biochemical Sciences
Volume	48
Issue number	4
Number of pages	4
ISSN	0968-0004
DOIs	https://doi.org/10.1016/j.tibs.2022.09.010
Publication status	Published - 2023

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Cite this

@article{1c664dc0c36c4525a56f62f69b1a7372,

title = "Did circular DNA shape the evolution of mammalian genomes?",

abstract = "Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.",

author = "Sylvester Holt and Gerard Arrey and Birgitte Regenberg",

year = "2023",

doi = "10.1016/j.tibs.2022.09.010",

language = "English",

volume = "48",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",