Discordance in Estimated GFR Among Hospitalized Older Adults

Esben Iversen; Ove Andersen; Morten Baltzer Houlind

doi:10.1016/j.xkme.2023.100743

Discordance in Estimated GFR Among Hospitalized Older Adults

Esben Iversen^*, Ove Andersen, Morten Baltzer Houlind

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Research › peer-review

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Abstract

Wang et al1 evaluated discordances in the estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr), cystatin C (eGFRcys), or their combination (eGFRcr-cys). They used data from the 2021 CKD-EPI external validation cohort, which included 4,050 ambulatory participants (mean age of 57.0 years and mean measured GFR [mGFR] of 76.4 mL/min/1.73m2).2 Defining eGFRdiff as a discordance between eGFRcys and eGFRcr larger than ±15 mL/min/1.73m2, the authors found that 21% of patients had a negative discordance (eGFRcr higher) and 10% had a positive discordance (eGFRcys higher). In both groups, eGFRcr-cys yielded the best performance relative to mGFR, according to bias and P30. The authors acknowledge that their study was limited by the lack of multimorbid or hospitalized patients.

Original language	English
Article number	100743
Journal	Kidney Medicine
Volume	5
Issue number	12
Number of pages	2
ISSN	2590-0595
DOIs	https://doi.org/10.1016/j.xkme.2023.100743
Publication status	Published - 2023

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@article{b35f1a7ca69c44178f4e61de894d66cf,

title = "Discordance in Estimated GFR Among Hospitalized Older Adults",

abstract = "Wang et al1 evaluated discordances in the estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr), cystatin C (eGFRcys), or their combination (eGFRcr-cys). They used data from the 2021 CKD-EPI external validation cohort, which included 4,050 ambulatory participants (mean age of 57.0 years and mean measured GFR [mGFR] of 76.4 mL/min/1.73m2).2 Defining eGFRdiff as a discordance between eGFRcys and eGFRcr larger than ±15 mL/min/1.73m2, the authors found that 21% of patients had a negative discordance (eGFRcr higher) and 10% had a positive discordance (eGFRcys higher). In both groups, eGFRcr-cys yielded the best performance relative to mGFR, according to bias and P30. The authors acknowledge that their study was limited by the lack of multimorbid or hospitalized patients.",

author = "Esben Iversen and Ove Andersen and Houlind, {Morten Baltzer}",

note = "Funding Information: The authors declare that they have no relevant financial interests. Received September 4, 2023. Accepted September 10, 2023 after editorial review by the Editor-in Chief.",

year = "2023",

doi = "10.1016/j.xkme.2023.100743",

language = "English",

volume = "5",

journal = "Kidney Medicine",

issn = "2590-0595",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - Discordance in Estimated GFR Among Hospitalized Older Adults

AU - Iversen, Esben

AU - Andersen, Ove

AU - Houlind, Morten Baltzer

N1 - Funding Information: The authors declare that they have no relevant financial interests. Received September 4, 2023. Accepted September 10, 2023 after editorial review by the Editor-in Chief.

PY - 2023

Y1 - 2023

N2 - Wang et al1 evaluated discordances in the estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr), cystatin C (eGFRcys), or their combination (eGFRcr-cys). They used data from the 2021 CKD-EPI external validation cohort, which included 4,050 ambulatory participants (mean age of 57.0 years and mean measured GFR [mGFR] of 76.4 mL/min/1.73m2).2 Defining eGFRdiff as a discordance between eGFRcys and eGFRcr larger than ±15 mL/min/1.73m2, the authors found that 21% of patients had a negative discordance (eGFRcr higher) and 10% had a positive discordance (eGFRcys higher). In both groups, eGFRcr-cys yielded the best performance relative to mGFR, according to bias and P30. The authors acknowledge that their study was limited by the lack of multimorbid or hospitalized patients.

AB - Wang et al1 evaluated discordances in the estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr), cystatin C (eGFRcys), or their combination (eGFRcr-cys). They used data from the 2021 CKD-EPI external validation cohort, which included 4,050 ambulatory participants (mean age of 57.0 years and mean measured GFR [mGFR] of 76.4 mL/min/1.73m2).2 Defining eGFRdiff as a discordance between eGFRcys and eGFRcr larger than ±15 mL/min/1.73m2, the authors found that 21% of patients had a negative discordance (eGFRcr higher) and 10% had a positive discordance (eGFRcys higher). In both groups, eGFRcr-cys yielded the best performance relative to mGFR, according to bias and P30. The authors acknowledge that their study was limited by the lack of multimorbid or hospitalized patients.

U2 - 10.1016/j.xkme.2023.100743

DO - 10.1016/j.xkme.2023.100743

M3 - Letter

C2 - 38116165

AN - SCOPUS:85176960157

VL - 5

JO - Kidney Medicine

JF - Kidney Medicine

SN - 2590-0595

IS - 12

M1 - 100743

ER -