Downregulation of Kv7.4 channel activity in primary and secondary hypertension

Thomas Andrew Jepps; Preet S Chadha; Alison J Davis; Maksym I Harhun; Gillian W Cockerill; Søren Peter Olesen; Rie S Hansen; Iain A Greenwood

doi:10.1161/CIRCULATIONAHA.111.032136

Downregulation of Kv7.4 channel activity in primary and secondary hypertension

Thomas Andrew Jepps, Preet S Chadha, Alison J Davis, Maksym I Harhun, Gillian W Cockerill, Søren Peter Olesen, Rie S Hansen, Iain A Greenwood

Physiology of circulation, kidney and lung

Research output: Contribution to journal › Journal article › Research › peer-review

127 Citations (Scopus)

Abstract

Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

Original language	English
Journal	Circulation
Volume	124
Issue number	5
Pages (from-to)	602-11
Number of pages	10
ISSN	0009-7322
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.111.032136
Publication status	Published - 2 Aug 2011

Keywords

Angiotensin II
Animals
Aorta, Thoracic
Blood Pressure
Carbamates
Down-Regulation
Hypertension
Indoles
KCNQ Potassium Channels
Male
Membrane Potentials
Mesenteric Arteries
Mice
Phenylenediamines
Rats
Rats, Inbred SHR
Rats, Wistar
Vasoconstrictor Agents

Access to Document

10.1161/CIRCULATIONAHA.111.032136

Cite this

Downregulation of Kv7.4 channel activity in primary and secondary hypertension. / Jepps, Thomas Andrew; Chadha, Preet S; Davis, Alison J; Harhun, Maksym I; Cockerill, Gillian W; Olesen, Søren Peter; Hansen, Rie S; Greenwood, Iain A.

In: Circulation, Vol. 124, No. 5, 02.08.2011, p. 602-11.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.",

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author = "Jepps, {Thomas Andrew} and Chadha, {Preet S} and Davis, {Alison J} and Harhun, {Maksym I} and Cockerill, {Gillian W} and Olesen, {S{\o}ren Peter} and Hansen, {Rie S} and Greenwood, {Iain A}",

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T1 - Downregulation of Kv7.4 channel activity in primary and secondary hypertension

AU - Jepps, Thomas Andrew

AU - Chadha, Preet S

AU - Davis, Alison J

AU - Harhun, Maksym I

AU - Cockerill, Gillian W

AU - Olesen, Søren Peter

AU - Hansen, Rie S

AU - Greenwood, Iain A

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N2 - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

AB - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.

KW - Angiotensin II

KW - Animals

KW - Aorta, Thoracic

KW - Blood Pressure

KW - Carbamates

KW - Down-Regulation

KW - Hypertension

KW - Indoles

KW - KCNQ Potassium Channels

KW - Male

KW - Membrane Potentials

KW - Mesenteric Arteries

KW - Mice

KW - Phenylenediamines

KW - Rats

KW - Rats, Inbred SHR

KW - Rats, Wistar

KW - Vasoconstrictor Agents

U2 - 10.1161/CIRCULATIONAHA.111.032136

DO - 10.1161/CIRCULATIONAHA.111.032136

M3 - Journal article

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VL - 124

SP - 602

EP - 611

JO - Circulation

JF - Circulation

SN - 0009-7322

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