Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems

Kent Jørgensen; Pernille Høyrup; Tina B. Pedersen; Ole G. Mouritsen

Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems

Kent Jørgensen, Pernille Høyrup, Tina B. Pedersen, Ole G. Mouritsen

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Abstract

The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A₂ enzymes, which are found at elevated concentrations at diseased sites.

Original language	English
Journal	Cellular and Molecular Biology Letters
Volume	6
Issue number	2A
Pages (from-to)	255-263
Number of pages	9
ISSN	1425-8153
Publication status	Published - 2001
Externally published	Yes

Keywords

Acylated Peptides
Computer Simulation
Drug Delivery
Fluorescence
Lipid Domain
Lipid Membranes
PEG-Liposomes
Phase Equilibria
Phase Transition
Phospholipase A

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title = "Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems",

abstract = "The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A2 enzymes, which are found at elevated concentrations at diseased sites.",

keywords = "Acylated Peptides, Computer Simulation, Drug Delivery, Fluorescence, Lipid Domain, Lipid Membranes, PEG-Liposomes, Phase Equilibria, Phase Transition, Phospholipase A",

author = "Kent J{\o}rgensen and Pernille H{\o}yrup and Pedersen, {Tina B.} and Mouritsen, {Ole G.}",

year = "2001",

language = "English",

volume = "6",

pages = "255--263",

journal = "Cellular & Molecular Biology Letters",

issn = "1425-8153",

publisher = "Versita",

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TY - JOUR

T1 - Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems

AU - Jørgensen, Kent

AU - Høyrup, Pernille

AU - Pedersen, Tina B.

AU - Mouritsen, Ole G.

PY - 2001

Y1 - 2001

N2 - The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A2 enzymes, which are found at elevated concentrations at diseased sites.

AB - The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A2 enzymes, which are found at elevated concentrations at diseased sites.

KW - Acylated Peptides

KW - Computer Simulation

KW - Drug Delivery

KW - Fluorescence

KW - Lipid Domain

KW - Lipid Membranes

KW - PEG-Liposomes

KW - Phase Equilibria

KW - Phase Transition

KW - Phospholipase A

M3 - Journal article

C2 - 11598644

AN - SCOPUS:0034796186

VL - 6

SP - 255

EP - 263

JO - Cellular & Molecular Biology Letters

JF - Cellular & Molecular Biology Letters

SN - 1425-8153

IS - 2A

ER -