Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice

Mette Munk Jensen; Kamille Dumong Erichsen; Fredrik Björkling; Jacob Madsen; Peter Buhl Jensen; Liselotte Højgaard; Maxwell Sehested; Andreas Kjær

doi:10.1371/journal.pone.0012965

Early detection of response to experimental chemotherapeutic Top216 with [¹⁸F]FLT and [¹⁸F]FDG PET in human ovary cancer xenografts in mice

Mette Munk Jensen, Kamille Dumong Erichsen, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Liselotte Højgaard, Maxwell Sehested, Andreas Kjær

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Abstract

3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of the experimental chemotherapy Top216 non-invasively by PET.

Original language	English
Journal	P L o S One
Volume	5
Issue number	9
Pages (from-to)	e12965
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0012965
Publication status	Published - 1 Jan 2010

Keywords

Animals
Antineoplastic Agents
Cell Proliferation
Dideoxynucleosides
Disease Models, Animal
Drug Monitoring
Female
Fluorodeoxyglucose F18
Humans
Mice
Mice, Nude
Ovarian Neoplasms
Positron-Emission Tomography
Radiopharmaceuticals
Xenograft Model Antitumor Assays

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10.1371/journal.pone.0012965

Cite this

Early detection of response to experimental chemotherapeutic Top216 with [¹⁸F]FLT and [¹⁸F]FDG PET in human ovary cancer xenografts in mice. / Jensen, Mette Munk; Erichsen, Kamille Dumong; Björkling, Fredrik; Madsen, Jacob; Jensen, Peter Buhl; Højgaard, Liselotte; Sehested, Maxwell; Kjær, Andreas.

In: P L o S One, Vol. 5, No. 9, 01.01.2010, p. e12965.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Madsen, Jacob

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AU - Højgaard, Liselotte

AU - Sehested, Maxwell

AU - Kjær, Andreas

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