Educational attainment does not influence brain aging

Lars Nyberg; Fredrik Magnussen; Anders Lundquist; William Baaré; David Bartrés-Faz; Lars Bertram; C. J. Boraxbekk; Andreas M. Brandmaier; Christian A. Drevon; Klaus Ebmeier; Paolo Ghisletta; Richard N. Henson; Carme Junqué; Rogier Kievit; Maike Kleemeyer; Ethan Knights; Simone Kühn; Ulman Lindenberger; Brenda W.J.H. Penninx; Sara Pudas; Øystein Sørensen; Lídia Vaqué-Alcázar; Kristine B. Walhovd; Anders M. Fjell

doi:10.1073/pnas.2101644118

Educational attainment does not influence brain aging

Lars Nyberg^*, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda W.J.H. Penninx, Sara PudasØystein Sørensen, Lídia Vaqué-Alcázar, Kristine B. Walhovd, Anders M. Fjell

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging.

Original language	English
Article number	2101644118
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	118
Issue number	18
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.2101644118
Publication status	Published - 2021

Bibliographical note

Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.

Keywords

Aging
Cerebral cortex
Education
Hippocampus
Reserve

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Nyberg, L., Magnussen, F., Lundquist, A., Baaré, W., Bartrés-Faz, D., Bertram, L., Boraxbekk, C. J., Brandmaier, A. M., Drevon, C. A., Ebmeier, K., Ghisletta, P., Henson, R. N., Junqué, C., Kievit, R., Kleemeyer, M., Knights, E., Kühn, S., Lindenberger, U., Penninx, B. W. J. H., ... Fjell, A. M. (2021). Educational attainment does not influence brain aging. Proceedings of the National Academy of Sciences of the United States of America, 118(18), [2101644118]. https://doi.org/10.1073/pnas.2101644118

Educational attainment does not influence brain aging. / Nyberg, Lars; Magnussen, Fredrik; Lundquist, Anders; Baaré, William; Bartrés-Faz, David; Bertram, Lars; Boraxbekk, C. J.; Brandmaier, Andreas M.; Drevon, Christian A.; Ebmeier, Klaus; Ghisletta, Paolo; Henson, Richard N.; Junqué, Carme; Kievit, Rogier; Kleemeyer, Maike; Knights, Ethan; Kühn, Simone; Lindenberger, Ulman; Penninx, Brenda W.J.H.; Pudas, Sara; Sørensen, Øystein; Vaqué-Alcázar, Lídia; Walhovd, Kristine B.; Fjell, Anders M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 18, 2101644118, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Nyberg, L, Magnussen, F, Lundquist, A, Baaré, W, Bartrés-Faz, D, Bertram, L, Boraxbekk, CJ, Brandmaier, AM, Drevon, CA, Ebmeier, K, Ghisletta, P, Henson, RN, Junqué, C, Kievit, R, Kleemeyer, M, Knights, E, Kühn, S, Lindenberger, U, Penninx, BWJH, Pudas, S, Sørensen, Ø, Vaqué-Alcázar, L, Walhovd, KB & Fjell, AM 2021, 'Educational attainment does not influence brain aging', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 18, 2101644118. https://doi.org/10.1073/pnas.2101644118

Nyberg, Lars ; Magnussen, Fredrik ; Lundquist, Anders ; Baaré, William ; Bartrés-Faz, David ; Bertram, Lars ; Boraxbekk, C. J. ; Brandmaier, Andreas M. ; Drevon, Christian A. ; Ebmeier, Klaus ; Ghisletta, Paolo ; Henson, Richard N. ; Junqué, Carme ; Kievit, Rogier ; Kleemeyer, Maike ; Knights, Ethan ; Kühn, Simone ; Lindenberger, Ulman ; Penninx, Brenda W.J.H. ; Pudas, Sara ; Sørensen, Øystein ; Vaqué-Alcázar, Lídia ; Walhovd, Kristine B. ; Fjell, Anders M. / Educational attainment does not influence brain aging. In: Proceedings of the National Academy of Sciences of the United States of America. 2021 ; Vol. 118, No. 18.

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abstract = "Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging.",

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Educational attainment does not influence brain aging

Abstract

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Keywords

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