TY - JOUR
T1 - Effect of glucagon-like peptide-2 exposure on bone resorption
T2 - Effectiveness of high concentration versus prolonged exposure
AU - Askov-Hansen, Carsten
AU - Jeppesen, Palle B
AU - Lund, Pernille
AU - Hartmann, Bolette
AU - Holst, Jens Juul
AU - Henriksen, Dennis B
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2013/2/10
Y1 - 2013/2/10
N2 - In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.
AB - In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.
U2 - 10.1016/j.regpep.2012.11.002
DO - 10.1016/j.regpep.2012.11.002
M3 - Journal article
C2 - 23261963
VL - 181
SP - 4
EP - 8
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
ER -