TY - JOUR
T1 - Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019
T2 - A Prospective Cohort Study of 46 000 Healthcare Workers( )
AU - Kristensen, Jonas Henrik
AU - Hasselbalch, Rasmus Bo
AU - Pries-Heje, Mia
AU - Nielsen, Pernille Brok
AU - Knudsen, Andreas Dehlbaek
AU - Fogh, Kamille
AU - Norsk, Jakob Boesgaard
AU - Eiken, Aleksander
AU - Andersen, Ove
AU - Fischer, Thea Kølsen
AU - Jensen, Claus Antonio Juul
AU - Torp-Pedersen, Christian
AU - Rungby, Jørgen
AU - Ditlev, Sisse Bolm
AU - Hageman, Ida
AU - Mogelvang, Rasmus
AU - Gybel-Brask, Mikkel
AU - Dessau, Ram Benny
AU - Sørensen, Erik
AU - Harritshøj, Lene
AU - Folke, Fredrik
AU - Moller, Maria Elizabeth Engel
AU - Benfield, Thomas
AU - Ullum, Henrik
AU - Jorgensen, Charlotte Svaerke
AU - Ostrowski, Sisse Rye
AU - Nielsen, Susanne Dam
AU - Bundgaard, Henning
AU - Iversen, Kasper
PY - 2022
Y1 - 2022
N2 - Background The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19). Methods A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination. Results The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found. Conclusions The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.This cohort study of 46 112 healthcare workers examined the effect of influenza vaccination on hospitalization and symptoms due to COVID-19 and development of antibodies against SARS-CoV-2. Influenza vaccination had no effect on the specified outcomes.
AB - Background The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19). Methods A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination. Results The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found. Conclusions The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.This cohort study of 46 112 healthcare workers examined the effect of influenza vaccination on hospitalization and symptoms due to COVID-19 and development of antibodies against SARS-CoV-2. Influenza vaccination had no effect on the specified outcomes.
KW - cohort study
KW - COVID-19
KW - healthcare workers
KW - influenza vaccination
KW - SARS-CoV-2
U2 - 10.1093/infdis/jiac001
DO - 10.1093/infdis/jiac001
M3 - Journal article
C2 - 34989811
VL - 226
SP - 6
EP - 10
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -