Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial

Robert Tweyongyere, Patrice A. Mawa, Macklyn Kihembo, Frances M. Jones, Emily L. Webb, Stephen Cose, David W. Dunne, Birgitte J Vennervald, Alison M. Elliott

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    Abstract

    Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown.
    Original languageEnglish
    JournalB M C Infectious Diseases
    Volume11
    Issue number234
    Number of pages13
    ISSN1471-2334
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Animals
    • Antibodies, Protozoan
    • Antigens, Protozoan
    • Antiprotozoal Agents
    • Cytokines
    • Female
    • Humans
    • Immunity, Maternally-Acquired
    • Infant
    • Infant, Newborn
    • Leukocytes, Mononuclear
    • Placebos
    • Praziquantel
    • Pregnancy
    • Pregnancy Complications, Parasitic
    • Schistosoma mansoni
    • Schistosomiasis mansoni
    • Treatment Outcome
    • Uganda

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