Abstract
Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown.
Original language | English |
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Journal | B M C Infectious Diseases |
Volume | 11 |
Issue number | 234 |
Number of pages | 13 |
ISSN | 1471-2334 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Antiprotozoal Agents
- Cytokines
- Female
- Humans
- Immunity, Maternally-Acquired
- Infant
- Infant, Newborn
- Leukocytes, Mononuclear
- Placebos
- Praziquantel
- Pregnancy
- Pregnancy Complications, Parasitic
- Schistosoma mansoni
- Schistosomiasis mansoni
- Treatment Outcome
- Uganda