Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

Alicia Lundby; Thomas Jespersen; Nicole Schmitt; Morten Grunnet; Søren-Peter Olesen; Jonathan M Cordeiro; Kirstine Calloe

doi:10.1111/j.1476-5381.2010.00859.x

Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

Alicia Lundby, Thomas Jespersen, Nicole Schmitt, Morten Grunnet, Søren-Peter Olesen, Jonathan M Cordeiro, Kirstine Calloe

Molecular Cardiology and Membrane Proteins

Research output: Contribution to journal › Journal article › Research

42 Citations (Scopus)

Abstract

The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.

Original language	English
Journal	British Journal of Pharmacology
Volume	160
Issue number	8
Pages (from-to)	2028-44
Number of pages	17
ISSN	0007-1188
DOIs	https://doi.org/10.1111/j.1476-5381.2010.00859.x
Publication status	Published - Aug 2010

Keywords

Animals
CHO Cells
Cloning, Molecular
Cricetinae
Cricetulus
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Humans
Ion Channel Gating
Kinetics
Kv Channel-Interacting Proteins
Kv1.4 Potassium Channel
Membrane Potentials
Nerve Tissue Proteins
Phenylurea Compounds
Potassium
Potassium Channels
Potassium Channels, Voltage-Gated
Shal Potassium Channels
Tetrazoles
Transfection
Xenopus laevis

Access to Document

10.1111/j.1476-5381.2010.00859.x

Cite this

Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2. / Lundby, Alicia; Jespersen, Thomas; Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter; Cordeiro, Jonathan M; Calloe, Kirstine.

In: British Journal of Pharmacology, Vol. 160, No. 8, 08.2010, p. 2028-44.

Research output: Contribution to journal › Journal article › Research

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abstract = "The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.",

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AU - Schmitt, Nicole

AU - Grunnet, Morten

AU - Olesen, Søren-Peter

AU - Cordeiro, Jonathan M

AU - Calloe, Kirstine

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KW - CHO Cells

KW - Cloning, Molecular

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KW - Cricetulus

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KW - Nerve Tissue Proteins

KW - Phenylurea Compounds

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KW - Potassium Channels

KW - Potassium Channels, Voltage-Gated

KW - Shal Potassium Channels

KW - Tetrazoles

KW - Transfection

KW - Xenopus laevis

U2 - 10.1111/j.1476-5381.2010.00859.x

DO - 10.1111/j.1476-5381.2010.00859.x

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