Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

Jens Steen Nielsen; Frederik Rode; Mette Rahbek; Karl-Erik Andersson; Lars Christian Rønn; Kirsten Bouchelouche; Jorgen Nordling; Pierre Bouchelouche

doi:10.1111/j.1464-410X.2010.10019.x

Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

Jens Steen Nielsen, Frederik Rode, Mette Rahbek, Karl-Erik Andersson, Lars Christian Rønn, Kirsten Bouchelouche, Jorgen Nordling, Pierre Bouchelouche

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Abstract

• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

Original language	English
Journal	B J U International (Print)
Volume	108
Issue number	5
Pages (from-to)	771-7
Number of pages	7
ISSN	1464-4096
DOIs	https://doi.org/10.1111/j.1464-410X.2010.10019.x
Publication status	Published - 2011

Access to Document

10.1111/j.1464-410X.2010.10019.x

Library access?

Check availability at the Royal Danish Library

Cite this

Nielsen, J. S., Rode, F., Rahbek, M., Andersson, K.-E., Rønn, L. C., Bouchelouche, K., Nordling, J., & Bouchelouche, P. (2011). Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. B J U International (Print), 108(5), 771-7. https://doi.org/10.1111/j.1464-410X.2010.10019.x

Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. / Nielsen, Jens Steen; Rode, Frederik; Rahbek, Mette et al.
In: B J U International (Print), Vol. 108, No. 5, 2011, p. 771-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, JS, Rode, F, Rahbek, M, Andersson, K-E, Rønn, LC, Bouchelouche, K, Nordling, J & Bouchelouche, P 2011, 'Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle', B J U International (Print), vol. 108, no. 5, pp. 771-7. https://doi.org/10.1111/j.1464-410X.2010.10019.x

@article{47718f7a53904c2289e95cbfd0ec60c6,

title = "Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle",

abstract = "• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.",

author = "Nielsen, {Jens Steen} and Frederik Rode and Mette Rahbek and Karl-Erik Andersson and R{\o}nn, {Lars Christian} and Kirsten Bouchelouche and Jorgen Nordling and Pierre Bouchelouche",

note = "{\textcopyright} 2011 THE AUTHORS. BJU INTERNATIONAL {\textcopyright} 2011 BJU INTERNATIONAL.",

year = "2011",

doi = "10.1111/j.1464-410X.2010.10019.x",

language = "English",

volume = "108",

pages = "771--7",

journal = "B J U International (Print)",

issn = "1464-4096",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

AU - Nielsen, Jens Steen

AU - Rode, Frederik

AU - Rahbek, Mette

AU - Andersson, Karl-Erik

AU - Rønn, Lars Christian

AU - Bouchelouche, Kirsten

AU - Nordling, Jorgen

AU - Bouchelouche, Pierre

PY - 2011

Y1 - 2011

N2 - • To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

AB - • To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

U2 - 10.1111/j.1464-410X.2010.10019.x

DO - 10.1111/j.1464-410X.2010.10019.x

M3 - Journal article

SN - 1464-4096

VL - 108

SP - 771

EP - 777

JO - B J U International (Print)

JF - B J U International (Print)

IS - 5

ER -