Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals

A Major-Pedersen, N Ihlemann, T S Hermann, B Christiansen, H Dominguez, B. Kveiborg, D B Nielsen, O L Svendsen, L Køber, C Torp-Pedersen

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20 Citations (Scopus)

Abstract

BACKGROUND/AIMS: Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. METHODS: We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. RESULTS: The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. CONCLUSION: Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.
Original languageEnglish
JournalExperimental Diabetes Research
Volume2008
Pages (from-to)672021
ISSN1687-5214
DOIs
Publication statusPublished - 2008

Bibliographical note

Keywords: Blood Glucose; Blood Pressure; Electrocardiography; Endothelium, Vascular; Glucose; Glucose Tolerance Test; Humans; Insulin; Kinetics; Placebos; Reference Values

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