Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review

Lauren Hellewell, Nakisa Malek Gilani, Christopher James Stanton, Ludovic Pelligand, Henrik Franzyk, Luca Guardabassi, Liam Good

Research output: Contribution to journalReviewResearchpeer-review

1 Citation (Scopus)
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Abstract

Aims: This systematic review was carried out to determine whether synthetic peptidomimetics exhibit significant advantages over antimicrobial peptides (AMPs) in terms of in vitro potency. Structural features - molecular weight, charge and length - were examined for correlations with activity. Methods: Original research articles reporting minimum inhibitory concentration (MIC) values against Escherichia coli, indexed until 31 December 2020, were searched in PubMed/ScienceDirect/Google Scholar and evaluated using mixed-effects models. Results: In vitro antimicrobial activity of peptidomimetics resembled that of AMPs. Net charge significantly affected MIC values (p < 0.001) with a trend of 4.6% decrease for increments in charge by +1. Conclusion: AMPs and antibacterial peptidomimetics exhibit similar potencies, providing an opportunity to exploit the advantageous stability and bioavailability typically associated with peptidomimetics.

Original languageEnglish
JournalFuture Medicinal Chemistry
Volume14
Issue number24
Pages (from-to)1899–1921
ISSN1756-8919
DOIs
Publication statusPublished - 2022

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