TY - JOUR
T1 - Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts
AU - Pedersen, Marie
AU - Gehring, Ulrike
AU - Beelen, Rob
AU - Wang, Meng
AU - Giorgis-Allemand, Lise
AU - Andersen, Anne-Marie Nybo
AU - Basagaña, Xavier
AU - Bernard, Claire
AU - Cirach, Marta
AU - Forastiere, Francesco
AU - de Hoogh, Kees
AU - Gražulevičienė, Regina
AU - Gruzieva, Olena
AU - Hoek, Gerard
AU - Jedynska, Aleksandra
AU - Klümper, Claudia
AU - Kooter, Ingeborg M
AU - Krämer, Ursula
AU - Kukkonen, Jaakko
AU - Porta, Daniela
AU - Postma, Dirkje S
AU - Raaschou-Nielsen, Ole
AU - van Rossem, Lenie
AU - Sunyer, Jordi
AU - Sørensen, Mette
AU - Tsai, Ming-Yi
AU - Vrijkotte, Tanja G
AU - Wilhelm, Michael
AU - Nieuwenhuijsen, Mark J
AU - Pershagen, Göran
AU - Brunekreef, Bert
AU - Kogevinas, Manolis
AU - Slama, Rémy
PY - 2016/1
Y1 - 2016/1
N2 - BACKGROUND: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn's size have been little examined.AIM: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW, weight<2,500 g among births after 37 weeks of gestation), mean birth weight and head circumference, relying on standardised fine-scale exposure assessment and with extensive control for potential confounders.METHODS: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM smaller than 2.5 and 10 µm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc) were calculated using random-effects regression on pooled data.RESULTS: A 200 ng/m(3) increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio, 1.36, 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10.CONCLUSION: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.
AB - BACKGROUND: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn's size have been little examined.AIM: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW, weight<2,500 g among births after 37 weeks of gestation), mean birth weight and head circumference, relying on standardised fine-scale exposure assessment and with extensive control for potential confounders.METHODS: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM smaller than 2.5 and 10 µm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc) were calculated using random-effects regression on pooled data.RESULTS: A 200 ng/m(3) increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio, 1.36, 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10.CONCLUSION: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.
U2 - 10.1289/ehp.1409546
DO - 10.1289/ehp.1409546
M3 - Journal article
C2 - 26046983
VL - 124
SP - 141
EP - 150
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 1
ER -