Abstract
The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.
Original language | English |
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Journal | Gut |
Volume | 47 |
Issue number | 3 |
Pages (from-to) | 370-6 |
Number of pages | 7 |
ISSN | 0017-5749 |
Publication status | Published - Sep 2000 |
Keywords
- Adaptation, Physiological
- Adult
- Aged
- Area Under Curve
- Case-Control Studies
- Fasting
- Female
- Glucagon
- Glucagon-Like Peptide 1
- Glucagon-Like Peptide 2
- Humans
- Ileum
- Male
- Middle Aged
- Peptide Fragments
- Peptides
- Postprandial Period
- Protein Precursors
- Radioimmunoassay
- Short Bowel Syndrome