Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

P B Jeppesen, B Hartmann, J Thulesen, B S Hansen, J J Holst, Steen Seier Poulsen, P B Mortensen

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178 Citations (Scopus)

Abstract

The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.
Original languageEnglish
JournalGut
Volume47
Issue number3
Pages (from-to)370-6
Number of pages7
ISSN0017-5749
Publication statusPublished - Sep 2000

Keywords

  • Adaptation, Physiological
  • Adult
  • Aged
  • Area Under Curve
  • Case-Control Studies
  • Fasting
  • Female
  • Glucagon
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptide 2
  • Humans
  • Ileum
  • Male
  • Middle Aged
  • Peptide Fragments
  • Peptides
  • Postprandial Period
  • Protein Precursors
  • Radioimmunoassay
  • Short Bowel Syndrome

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