Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system

Philip J. Sassene; Mette D. Mosgaard; Korbinian Löbmann; Huiling Mu; Flemming Hofmann Larsen; Thomas Rades; Anette Müllertz

doi:10.1021/acs.molpharmaceut.5b00498

Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system

Philip J. Sassene, Mette D. Mosgaard, Korbinian Löbmann, Huiling Mu, Flemming Hofmann Larsen, Thomas Rades, Anette Müllertz

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Original language	English
Journal	Molecular Pharmaceutics
Volume	12
Issue number	11
Pages (from-to)	4067-4076
Number of pages	10
ISSN	1543-8384
DOIs	https://doi.org/10.1021/acs.molpharmaceut.5b00498
Publication status	Published - 2015

Keywords

lipid-based drug delivery systems
self-nanoemuslifying drug delivery systems
nuclear magnetic resonance spectroscopy
differential scanning calorimetry
solid-state characterization
amorphous
weak bases
interactions

Access to Document

10.1021/acs.molpharmaceut.5b00498

Cite this

Sassene, P. J., Mosgaard, M. D., Löbmann, K., Mu, H., Larsen, F. H., Rades, T., & Müllertz, A. (2015). Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system. Molecular Pharmaceutics, 12(11), 4067-4076. https://doi.org/10.1021/acs.molpharmaceut.5b00498

Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations : a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system. / Sassene, Philip J.; Mosgaard, Mette D.; Löbmann, Korbinian ; Mu, Huiling; Larsen, Flemming Hofmann; Rades, Thomas ; Müllertz, Anette.

In: Molecular Pharmaceutics, Vol. 12, No. 11, 2015, p. 4067-4076.

Research output: Contribution to journal › Journal article › Research › peer-review

Sassene, PJ, Mosgaard, MD, Löbmann, K , Mu, H, Larsen, FH, Rades, T & Müllertz, A 2015, 'Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system', Molecular Pharmaceutics, vol. 12, no. 11, pp. 4067-4076. https://doi.org/10.1021/acs.molpharmaceut.5b00498

Sassene PJ, Mosgaard MD, Löbmann K , Mu H, Larsen FH, Rades T et al. Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system. Molecular Pharmaceutics. 2015;12(11):4067-4076. https://doi.org/10.1021/acs.molpharmaceut.5b00498

Sassene, Philip J. ; Mosgaard, Mette D. ; Löbmann, Korbinian ; Mu, Huiling ; Larsen, Flemming Hofmann ; Rades, Thomas ; Müllertz, Anette. / Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations : a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system. In: Molecular Pharmaceutics. 2015 ; Vol. 12, No. 11. pp. 4067-4076.

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