EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle

Thomas Elbenhardt Jensen, Robin Leutert, Søren T Rasmussen, Joshua Roger Mouatt, Mette Landau Brabæk Christiansen, Bente Rona Jensen, Erik A. Richter

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    23 Citations (Scopus)

    Abstract

    In mice, certain proteins show a highly confined expression in specific muscle groups. Also, resting and exercise/contraction-induced phosphorylation responses are higher in rat skeletal muscle with low mitochondrial content compared to muscles with high mitochondrial content, possibly related to differential reactive oxygen species (ROS)-scavenging ability or resting glycogen content. To evaluate these parameters in humans, biopsies from soleus, gastrocnemius and vastus lateralis muscles were taken before and after a 45 min inclined (15%) walking exercise bout at 69% VO2(max) aimed at simultaneously activating soleus and gastrocnemius in a comparable dynamic work-pattern. Hexokinase II and GLUT4 were 46-59% and 26-38% higher (p
    Original languageEnglish
    JournalP L o S One
    Volume7
    Issue number2
    Pages (from-to)e31054
    Number of pages8
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Electromyography
    • Enzyme Activation
    • Exercise
    • Glucose Transporter Type 4
    • Hexokinase
    • Humans
    • Muscle, Skeletal
    • Phosphorylation
    • Protein Kinases
    • Signal Transduction

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