Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei

N A Ankrah; A Sittie; P G Addo; F A Ekuban

Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei

N A Ankrah, A Sittie, P G Addo, F A Ekuban

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

The effect of dietary aflatoxins B1 and G1 and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.

Original language	English
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	89
Issue number	1
Pages (from-to)	59-61
Number of pages	2
ISSN	0035-9203
Publication status	Published - 1995

Bibliographical note

Keywords: Aflatoxin B1; Aflatoxins; Animals; Female; Glutathione; Liver; Liver Diseases, Parasitic; Malaria; Male; Mice; Parasitemia; Plasmodium berghei

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title = "Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei",

abstract = "The effect of dietary aflatoxins B1 and G1 and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.",

author = "Ankrah, {N A} and A Sittie and Addo, {P G} and Ekuban, {F A}",

note = "Keywords: Aflatoxin B1; Aflatoxins; Animals; Female; Glutathione; Liver; Liver Diseases, Parasitic; Malaria; Male; Mice; Parasitemia; Plasmodium berghei",

year = "1995",

language = "English",

volume = "89",

pages = "59--61",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Enhanced depletion of glutathione and increased liver oxidative damage in aflatoxin-fed mice infected with Plasmodium berghei

AU - Ankrah, N A

AU - Sittie, A

AU - Addo, P G

AU - Ekuban, F A

N1 - Keywords: Aflatoxin B1; Aflatoxins; Animals; Female; Glutathione; Liver; Liver Diseases, Parasitic; Malaria; Male; Mice; Parasitemia; Plasmodium berghei

PY - 1995

Y1 - 1995

N2 - The effect of dietary aflatoxins B1 and G1 and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.

AB - The effect of dietary aflatoxins B1 and G1 and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.

M3 - Journal article

C2 - 7747309

SN - 0035-9203

VL - 89

SP - 59

EP - 61

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 1

ER -