TY - JOUR
T1 - Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS)
T2 - A worldwide platform for collaboration
AU - Paschou, Peristera
AU - Jin, Yin
AU - Müller-Vahl, Kirsten
AU - Möller, Harald E.
AU - Rizzo, Renata
AU - Hoekstra, Pieter J.
AU - Roessner, Veit
AU - Debes, Nanette Mol
AU - Worbe, Yulia
AU - Hartmann, Andreas
AU - Mir, Pablo
AU - Cath, Danielle
AU - Neuner, Irene
AU - Eichele, Heike
AU - Zhang, Chencheng
AU - Lewandowska, Katarzyna
AU - Munchau, Alexander
AU - Verrel, Julius
AU - Musil, Richard
AU - Silk, Tim J.
AU - Hanlon, Colleen A.
AU - Bihun, Emily D.
AU - Brandt, Valerie
AU - Dietrich, Andrea
AU - Forde, Natalie
AU - Ganos, Christos
AU - Greene, Deanna J.
AU - Chu, Chunguang
AU - Grothe, Michel J
AU - Hershey, Tamara
AU - Janik, Piotr
AU - Koller, Jonathan M.
AU - Martin-Rodriguez, Juan Francisco
AU - Müller, Karsten
AU - Palmucci, Stefano
AU - Prato, Adriana
AU - Ramkiran, Shukti
AU - Saia, Federica
AU - Szejko, Natalia
AU - Torrecuso, Renzo
AU - Tumer, Zeynep
AU - Uhlmann, Anne
AU - Veselinovic, Tanja
AU - Wolańczyk, Tomasz
AU - Zouki, Jade Jocelyne
AU - Jain, Pritesh
AU - Topaloudi, Apostolia
AU - Kaka, Mary
AU - Yang, Zhiyu
AU - Drineas, Petros
AU - Thomopoulos, Sophia I.
AU - White, Tonya
AU - Veltman, Dick J
AU - Schmaal, Lianne
AU - Stein, Dan J
AU - Buitelaar, Jan
AU - Franke, Barbara
AU - van den Heuvel, Odile
AU - Jahanshad, Neda
AU - Thompson, Paul M.
AU - Black, Kevin J.
N1 - Publisher Copyright:
Copyright © 2022 Paschou, Jin, Müller-Vahl, Möller, Rizzo, Hoekstra, Roessner, Mol Debes, Worbe, Hartmann, Mir, Cath, Neuner, Eichele, Zhang, Lewandowska, Munchau, Verrel, Musil, Silk, Hanlon, Bihun, Brandt, Dietrich, Forde, Ganos, Greene, Chu, Grothe, Hershey, Janik, Koller, Martin-Rodriguez, Müller, Palmucci, Prato, Ramkiran, Saia, Szejko, Torrecuso, Tumer, Uhlmann, Veselinovic, Wolańczyk, Zouki, Jain, Topaloudi, Kaka, Yang, Drineas, Thomopoulos, White, Veltman, Schmaal, Stein, Buitelaar, Franke, van den Heuvel, Jahanshad, Thompson and Black.
PY - 2022
Y1 - 2022
N2 - Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.
AB - Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.
KW - brain MRI
KW - ENIGMA
KW - genetics
KW - neuroimaging
KW - Tourette syndrome
U2 - 10.3389/fpsyt.2022.958688
DO - 10.3389/fpsyt.2022.958688
M3 - Journal article
C2 - 36072455
AN - SCOPUS:85138038855
VL - 13
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
SN - 1664-0640
M1 - 958688
ER -