Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

Jesper A B Strickertsson; Claus Desler Madsen; Tomas Martin-Bertelsen; Ana Manuel Dantas Machado; Torkel Wadstrøm; Ole Winther; Lene Juel Rasmussen; Lennart Friis-Hansen

doi:10.1371/journal.pone.0063147

Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

Jesper A B Strickertsson, Claus Desler Madsen, Tomas Martin-Bertelsen, Ana Manuel Dantas Machado, Torkel Wadstrøm, Ole Winther, Lene Juel Rasmussen, Lennart Friis-Hansen

Research output: Contribution to journal › Journal article › Research › peer-review

72 Citations (Scopus)

1040 Downloads (Pure)

Abstract

Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells.

Original language	English
Article number	e63147
Journal	PLOS ONE
Volume	8
Issue number	4
Pages (from-to)	1-13
Number of pages	13
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0063147
Publication status	Published - 2013

Access to Document

10.1371/journal.pone.0063147

journal.pone.0063147Final published version, 1.93 MB

Cite this

Strickertsson, J. A. B., Madsen, C. D., Martin-Bertelsen, T., Machado, A. M. D., Wadstrøm, T., Winther, O., Rasmussen, L. J., & Friis-Hansen, L. (2013). Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. PLOS ONE, 8(4), 1-13. [e63147]. https://doi.org/10.1371/journal.pone.0063147

Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Martin-Bertelsen, Tomas; Machado, Ana Manuel Dantas; Wadstrøm, Torkel; Winther, Ole ; Rasmussen, Lene Juel ; Friis-Hansen, Lennart.

In: PLOS ONE, Vol. 8, No. 4, e63147, 2013, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Strickertsson, Jesper A B ; Madsen, Claus Desler ; Martin-Bertelsen, Tomas ; Machado, Ana Manuel Dantas ; Wadstrøm, Torkel ; Winther, Ole ; Rasmussen, Lene Juel ; Friis-Hansen, Lennart. / Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. In: PLOS ONE. 2013 ; Vol. 8, No. 4. pp. 1-13.

@article{9161f4b8fc4f490bbb6bc23e53693db7,

title = "Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells",

abstract = "Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells.",

author = "Strickertsson, {Jesper A B} and Madsen, {Claus Desler} and Tomas Martin-Bertelsen and Machado, {Ana Manuel Dantas} and Torkel Wadstr{\o}m and Ole Winther and Rasmussen, {Lene Juel} and Lennart Friis-Hansen",

year = "2013",

doi = "10.1371/journal.pone.0063147",

language = "English",

volume = "8",

pages = "1--13",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "4",

}

TY - JOUR

T1 - Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

AU - Strickertsson, Jesper A B

AU - Madsen, Claus Desler

AU - Martin-Bertelsen, Tomas

AU - Machado, Ana Manuel Dantas

AU - Wadstrøm, Torkel

AU - Winther, Ole

AU - Rasmussen, Lene Juel

AU - Friis-Hansen, Lennart

PY - 2013

Y1 - 2013

N2 - Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells.

AB - Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells.

U2 - 10.1371/journal.pone.0063147

DO - 10.1371/journal.pone.0063147

M3 - Journal article

C2 - 23646188

VL - 8

SP - 1

EP - 13

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 4

M1 - e63147

ER -