Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

Jesper A B Strickertsson; Claus Desler Madsen; Tomas Martin-Bertelsen; Ana Manuel Dantas Machado; Torkel Wadstrøm; Ole Winther; Lene Juel Rasmussen; Lennart Friis-Hansen

doi:10.1371/journal.pone.0063147

Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

Jesper A B Strickertsson, Claus Desler Madsen, Tomas Martin-Bertelsen, Ana Manuel Dantas Machado, Torkel Wadstrøm, Ole Winther, Lene Juel Rasmussen, Lennart Friis-Hansen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells.

Original language	English
Article number	e63147
Journal	PLOS ONE
Volume	8
Issue number	4
Pages (from-to)	1-13
Number of pages	13
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0063147
Publication status	Published - 2013

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Strickertsson, J. A. B., Madsen, C. D., Martin-Bertelsen, T., Machado, A. M. D., Wadstrøm, T., Winther, O., Rasmussen, L. J., & Friis-Hansen, L. (2013). Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. PLOS ONE, 8(4), 1-13. [e63147]. https://doi.org/10.1371/journal.pone.0063147

Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Martin-Bertelsen, Tomas; Machado, Ana Manuel Dantas; Wadstrøm, Torkel; Winther, Ole ; Rasmussen, Lene Juel ; Friis-Hansen, Lennart.

In: PLOS ONE, Vol. 8, No. 4, e63147, 2013, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Strickertsson, Jesper A B ; Madsen, Claus Desler ; Martin-Bertelsen, Tomas ; Machado, Ana Manuel Dantas ; Wadstrøm, Torkel ; Winther, Ole ; Rasmussen, Lene Juel ; Friis-Hansen, Lennart. / Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. In: PLOS ONE. 2013 ; Vol. 8, No. 4. pp. 1-13.

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