Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

Emil Andersen; Ali Altıntaş; Ulrika Andersson-Hall; Agneta Holmäng; Romain Barrès

doi:10.2217/epi-2019-0055

Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

Emil Andersen, Ali Altıntaş, Ulrika Andersson-Hall, Agneta Holmäng, Romain Barrès

Zierath Group

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.

METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.

RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.

CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.

CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.

Original language	English
Journal	Epigenomics
Volume	11
Issue number	8
Pages (from-to)	861-873
Number of pages	14
ISSN	1750-1911
DOIs	https://doi.org/10.2217/epi-2019-0055
Publication status	Published - 2019

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Environmental factors influence theepigenetic signature of newborns frommothers with gestational diabetesFinal published version, 1.55 MB

Cite this

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title = "Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes",

abstract = "AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.",

author = "Emil Andersen and Ali Altınta{\c s} and Ulrika Andersson-Hall and Agneta Holm{\"a}ng and Romain Barr{\`e}s",

year = "2019",

doi = "10.2217/epi-2019-0055",

language = "English",

volume = "11",

pages = "861--873",

journal = "Epigenomics",

issn = "1750-1911",

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T1 - Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

AU - Andersen, Emil

AU - Altıntaş, Ali

AU - Andersson-Hall, Ulrika

AU - Holmäng, Agneta

AU - Barrès, Romain

PY - 2019

Y1 - 2019

N2 - AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.

AB - AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.

U2 - 10.2217/epi-2019-0055

DO - 10.2217/epi-2019-0055

M3 - Journal article

C2 - 30966798

SN - 1750-1911

VL - 11

SP - 861

EP - 873

JO - Epigenomics

JF - Epigenomics

IS - 8

ER -