Epidemiological studies of the non-specific effects of vaccines: II--methodological issues in the design and analysis of cohort studies

C P Farrington, M J Firth, L H Moulton, H Ravn, S Evans, Working Group on Non-specific Effects of Vaccines, Per Kragh Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

41 Citations (Scopus)

Abstract

We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.
Original languageEnglish
JournalTropical Medicine & International Health
Volume14
Issue number9
Pages (from-to)977-85
Number of pages8
ISSN1360-2276
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Bias (Epidemiology); Child, Preschool; Cohort Studies; Forms and Records Control; Humans; Infant; Medical Records; Vaccination; Vaccines

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