Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Muhammad Shoaib; Claus Storgaard Sørensen

doi:10.1016/j.ccell.2015.10.009

Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Muhammad Shoaib, Claus Storgaard Sørensen

Sørensen Group

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

Original language	English
Journal	Cancer Cell
Volume	28
Issue number	5
Pages (from-to)	545-547
Number of pages	3
ISSN	1535-6108
DOIs	https://doi.org/10.1016/j.ccell.2015.10.009
Publication status	Published - 9 Nov 2015

Keywords

Animals
Cell Cycle Proteins
Histones
Humans
Neoplasms
Nuclear Proteins
Nucleotides
Protein-Tyrosine Kinases
Comment
Journal Article

Access to Document

10.1016/j.ccell.2015.10.009

Cite this

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title = "Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave",

abstract = "Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.",

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KW - Animals

KW - Cell Cycle Proteins

KW - Histones

KW - Humans

KW - Neoplasms

KW - Nuclear Proteins

KW - Nucleotides

KW - Protein-Tyrosine Kinases

KW - Comment

KW - Journal Article

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DO - 10.1016/j.ccell.2015.10.009

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JO - Cancer Cell

JF - Cancer Cell

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