Erythrocyte-methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis

K Kristensen; S Nielsen; F Karup Pedersen; M Zak

Erythrocyte-methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis

K Kristensen, S Nielsen, F Karup Pedersen, M Zak

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

The concentration of methotrexate (MTX) in erythrocytes (E-MTX) was measured twice with three months interval in 21 children suffering from juvenile chronic arthritis (JCA). At the same time joint score, visual analogue scale (VAS), and laboratory parameters (CRP, WBC, PMNs, and ALAT) were obtained. There was only a weak insignificant correlation between the dose of MTX/m2 and E-MTX (r=0.24, p=0.11). No significant relations between the clinical or laboratory parameters and E-MTX was found. However, ALAT above normal range was associated with a lower dose of MTX (p=0.02) and lower VAS (p=0.02), indicating that toxicity may be associated with less articular discomfort. At present we consider routine determination of E-MTX in children with JCA of limited value.

Original language	English
Journal	Scandinavian Journal of Rheumatology
Volume	29
Issue number	3
Pages (from-to)	187-9
Number of pages	3
ISSN	0300-9742
Publication status	Published - 1 Jan 2000

Keywords

Administration, Oral
Adolescent
Alanine Transaminase
Antirheumatic Agents
Arthritis, Juvenile Rheumatoid
C-Reactive Protein
Child
Child, Preschool
Erythrocytes
Humans
Leukocyte Count
Methotrexate
Prospective Studies
Severity of Illness Index

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@article{a8e305a2012c4611ad8910a6b31003e0,

title = "Erythrocyte-methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis",

abstract = "The concentration of methotrexate (MTX) in erythrocytes (E-MTX) was measured twice with three months interval in 21 children suffering from juvenile chronic arthritis (JCA). At the same time joint score, visual analogue scale (VAS), and laboratory parameters (CRP, WBC, PMNs, and ALAT) were obtained. There was only a weak insignificant correlation between the dose of MTX/m2 and E-MTX (r=0.24, p=0.11). No significant relations between the clinical or laboratory parameters and E-MTX was found. However, ALAT above normal range was associated with a lower dose of MTX (p=0.02) and lower VAS (p=0.02), indicating that toxicity may be associated with less articular discomfort. At present we consider routine determination of E-MTX in children with JCA of limited value.",

keywords = "Administration, Oral, Adolescent, Alanine Transaminase, Antirheumatic Agents, Arthritis, Juvenile Rheumatoid, C-Reactive Protein, Child, Child, Preschool, Erythrocytes, Humans, Leukocyte Count, Methotrexate, Prospective Studies, Severity of Illness Index",

author = "K Kristensen and S Nielsen and {Karup Pedersen}, F and M Zak",

year = "2000",

month = jan,

day = "1",

language = "English",

volume = "29",

pages = "187--9",

journal = "Scandinavian Journal of Rheumatology",

issn = "0300-9742",

publisher = "Taylor & Francis",

number = "3",

}

TY - JOUR

T1 - Erythrocyte-methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis

AU - Kristensen, K

AU - Nielsen, S

AU - Karup Pedersen, F

AU - Zak, M

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The concentration of methotrexate (MTX) in erythrocytes (E-MTX) was measured twice with three months interval in 21 children suffering from juvenile chronic arthritis (JCA). At the same time joint score, visual analogue scale (VAS), and laboratory parameters (CRP, WBC, PMNs, and ALAT) were obtained. There was only a weak insignificant correlation between the dose of MTX/m2 and E-MTX (r=0.24, p=0.11). No significant relations between the clinical or laboratory parameters and E-MTX was found. However, ALAT above normal range was associated with a lower dose of MTX (p=0.02) and lower VAS (p=0.02), indicating that toxicity may be associated with less articular discomfort. At present we consider routine determination of E-MTX in children with JCA of limited value.

AB - The concentration of methotrexate (MTX) in erythrocytes (E-MTX) was measured twice with three months interval in 21 children suffering from juvenile chronic arthritis (JCA). At the same time joint score, visual analogue scale (VAS), and laboratory parameters (CRP, WBC, PMNs, and ALAT) were obtained. There was only a weak insignificant correlation between the dose of MTX/m2 and E-MTX (r=0.24, p=0.11). No significant relations between the clinical or laboratory parameters and E-MTX was found. However, ALAT above normal range was associated with a lower dose of MTX (p=0.02) and lower VAS (p=0.02), indicating that toxicity may be associated with less articular discomfort. At present we consider routine determination of E-MTX in children with JCA of limited value.

KW - Administration, Oral

KW - Adolescent

KW - Alanine Transaminase

KW - Antirheumatic Agents

KW - Arthritis, Juvenile Rheumatoid

KW - C-Reactive Protein

KW - Child

KW - Child, Preschool

KW - Erythrocytes

KW - Humans

KW - Leukocyte Count

KW - Methotrexate

KW - Prospective Studies

KW - Severity of Illness Index

M3 - Journal article

C2 - 10898073

SN - 0300-9742

VL - 29

SP - 187

EP - 189

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

IS - 3

ER -