Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome

Alberto Muñoz-Prieto; José J. Cerón; Camila P. Rubio; María Dolores Contreras-Aguilar; Luis Pardo-Marín; Ignacio Ayala-de la Peña; María Martín-Cuervo; Ida Marie Holm Henriksen; Julián J. Arense-Gonzalo; Fernando Tecles; Sanni Hansen

doi:10.3390/ani12233261

Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome

Alberto Muñoz-Prieto, José J. Cerón, Camila P. Rubio, María Dolores Contreras-Aguilar, Luis Pardo-Marín, Ignacio Ayala-de la Peña, María Martín-Cuervo, Ida Marie Holm Henriksen, Julián J. Arense-Gonzalo, Fernando Tecles^*, Sanni Hansen

^*Corresponding author for this work

Section for Medicine and Surgery

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

12 Downloads (Pure)

Abstract

In this report, the measurement of salivary biomarkers as an aid for diagnosis of equine gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was measured in the saliva of horses affected by EGUS and compared to healthy animals and horses with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination. A total of 147 horses were included in the study and divided into heathy population (n = 12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23 analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to the group of other diseases. The receiver operating characteristic curve analyses showed a modest but significant discriminatory power of those three analytes to identify EGUS from other diseases with similar symptoms. The discriminatory power enhanced when the results of the three analytes were combined. In conclusion, the results showed that selected salivary analytes could have potential use as biomarkers in horses with EGUS.

Original language	English
Article number	3261
Journal	Animals
Volume	12
Issue number	23
ISSN	2076-2615
DOIs	https://doi.org/10.3390/ani12233261
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

biomarkers
diagnosis
equine gastric ulcer syndrome
horse
saliva

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Cite this

Muñoz-Prieto, A., Cerón, J. J., Rubio, C. P., Contreras-Aguilar, M. D., Pardo-Marín, L., Ayala-de la Peña, I., Martín-Cuervo, M., Holm Henriksen, I. M., Arense-Gonzalo, J. J., Tecles, F., & Hansen, S. (2022). Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome. Animals, 12(23), [3261]. https://doi.org/10.3390/ani12233261

Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome. / Muñoz-Prieto, Alberto; Cerón, José J.; Rubio, Camila P.; Contreras-Aguilar, María Dolores; Pardo-Marín, Luis; Ayala-de la Peña, Ignacio; Martín-Cuervo, María; Holm Henriksen, Ida Marie; Arense-Gonzalo, Julián J.; Tecles, Fernando; Hansen, Sanni.

In: Animals, Vol. 12, No. 23, 3261, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Muñoz-Prieto, A, Cerón, JJ, Rubio, CP, Contreras-Aguilar, MD, Pardo-Marín, L, Ayala-de la Peña, I, Martín-Cuervo, M, Holm Henriksen, IM, Arense-Gonzalo, JJ, Tecles, F & Hansen, S 2022, 'Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome', Animals, vol. 12, no. 23, 3261. https://doi.org/10.3390/ani12233261

Muñoz-Prieto, Alberto ; Cerón, José J. ; Rubio, Camila P. ; Contreras-Aguilar, María Dolores ; Pardo-Marín, Luis ; Ayala-de la Peña, Ignacio ; Martín-Cuervo, María ; Holm Henriksen, Ida Marie ; Arense-Gonzalo, Julián J. ; Tecles, Fernando ; Hansen, Sanni. / Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome. In: Animals. 2022 ; Vol. 12, No. 23.

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abstract = "In this report, the measurement of salivary biomarkers as an aid for diagnosis of equine gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was measured in the saliva of horses affected by EGUS and compared to healthy animals and horses with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination. A total of 147 horses were included in the study and divided into heathy population (n = 12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23 analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to the group of other diseases. The receiver operating characteristic curve analyses showed a modest but significant discriminatory power of those three analytes to identify EGUS from other diseases with similar symptoms. The discriminatory power enhanced when the results of the three analytes were combined. In conclusion, the results showed that selected salivary analytes could have potential use as biomarkers in horses with EGUS.",

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AU - Contreras-Aguilar, María Dolores

AU - Pardo-Marín, Luis

AU - Ayala-de la Peña, Ignacio

AU - Martín-Cuervo, María

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AB - In this report, the measurement of salivary biomarkers as an aid for diagnosis of equine gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was measured in the saliva of horses affected by EGUS and compared to healthy animals and horses with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination. A total of 147 horses were included in the study and divided into heathy population (n = 12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23 analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to the group of other diseases. The receiver operating characteristic curve analyses showed a modest but significant discriminatory power of those three analytes to identify EGUS from other diseases with similar symptoms. The discriminatory power enhanced when the results of the three analytes were combined. In conclusion, the results showed that selected salivary analytes could have potential use as biomarkers in horses with EGUS.

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