Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity

Thomas P J Solomon; Sine H Knudsen; Kristian Karstoft; Kamilla Winding; Jens Juul Holst; Bente K Pedersen

doi:10.1210/jc.2012-2097

Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity

Thomas P J Solomon, Sine H Knudsen, Kristian Karstoft, Kamilla Winding, Jens Juul Holst, Bente K Pedersen

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

Abstract

Investigating the impact of hyperglycemia on pancreatic endocrine function promotes our understanding of the pathophysiology of hyperglycemia-related disease.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	97
Issue number	12
Pages (from-to)	4682-91
Number of pages	10
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2012-2097
Publication status	Published - Dec 2012

Keywords

Blood Glucose
Cross-Over Studies
Diabetes Mellitus, Type 2
Female
Glucagon
Glucose
Glucose Clamp Technique
Humans
Hyperglycemia
Insulin
Islets of Langerhans
Male
Middle Aged
Pancreatic Hormones

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title = "Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity",

abstract = "Investigating the impact of hyperglycemia on pancreatic endocrine function promotes our understanding of the pathophysiology of hyperglycemia-related disease.",

keywords = "Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 2, Female, Glucagon, Glucose, Glucose Clamp Technique, Humans, Hyperglycemia, Insulin, Islets of Langerhans, Male, Middle Aged, Pancreatic Hormones",

author = "Solomon, {Thomas P J} and Knudsen, {Sine H} and Kristian Karstoft and Kamilla Winding and Holst, {Jens Juul} and Pedersen, {Bente K}",

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T2 - evidence for in vivo glucotoxicity

AU - Solomon, Thomas P J

AU - Knudsen, Sine H

AU - Karstoft, Kristian

AU - Winding, Kamilla

AU - Holst, Jens Juul

AU - Pedersen, Bente K

PY - 2012/12

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AB - Investigating the impact of hyperglycemia on pancreatic endocrine function promotes our understanding of the pathophysiology of hyperglycemia-related disease.

KW - Blood Glucose

KW - Cross-Over Studies

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Glucagon

KW - Glucose

KW - Glucose Clamp Technique

KW - Humans

KW - Hyperglycemia

KW - Insulin

KW - Islets of Langerhans

KW - Male

KW - Middle Aged

KW - Pancreatic Hormones

U2 - 10.1210/jc.2012-2097

DO - 10.1210/jc.2012-2097

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VL - 97

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EP - 4691

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

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