TY - JOUR
T1 - Exercise and health — emerging roles of IL-6
AU - Ellingsgaard, Helga
AU - Hojman, Pernille
AU - Pedersen, Bente Klarlund
PY - 2019
Y1 - 2019
N2 - Skeletal muscle works as a secretory organ with the capacity to produce hundreds of myokines. This finding provides a conceptual basis for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. The myokine IL-6 is released into the blood during exercise and it has been shown that IL-6 has multiple immunologic and metabolic effects. Here, we discuss recent advances regarding the physiology of IL-6. Human studies show that IL-6 infusion delays gastric emptying, reduces postprandial glucose concentrations and reduces insulin secretion, whereas experimental studies suggest a role for IL-6 in appetite regulation. Evidence is also accumulating for a central role of IL-6 in training-induced loss of visceral adipose tissue mass in humans. Moreover, recent experimental studies in mice show that voluntary exercise suppresses tumor growth through epinephrine-dependent and IL-6-dependent mobilization and redistribution of cytotoxic NK cells. It has been known for a while that IL-6 is a pleiotropic molecule; however, recent advances suggest that the physiological roles of IL-6 involve multiple aspects of metabolism as well as a role in tumor defense.
AB - Skeletal muscle works as a secretory organ with the capacity to produce hundreds of myokines. This finding provides a conceptual basis for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. The myokine IL-6 is released into the blood during exercise and it has been shown that IL-6 has multiple immunologic and metabolic effects. Here, we discuss recent advances regarding the physiology of IL-6. Human studies show that IL-6 infusion delays gastric emptying, reduces postprandial glucose concentrations and reduces insulin secretion, whereas experimental studies suggest a role for IL-6 in appetite regulation. Evidence is also accumulating for a central role of IL-6 in training-induced loss of visceral adipose tissue mass in humans. Moreover, recent experimental studies in mice show that voluntary exercise suppresses tumor growth through epinephrine-dependent and IL-6-dependent mobilization and redistribution of cytotoxic NK cells. It has been known for a while that IL-6 is a pleiotropic molecule; however, recent advances suggest that the physiological roles of IL-6 involve multiple aspects of metabolism as well as a role in tumor defense.
U2 - 10.1016/j.cophys.2019.03.009
DO - 10.1016/j.cophys.2019.03.009
M3 - Review
AN - SCOPUS:85065835997
VL - 10
SP - 49
EP - 54
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
SN - 2468-8681
ER -