Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

Martin Friedrichsen, Brynjulf Mortensen, Christian Pehmøller, Jesper Bratz Birk, Jørgen Wojtaszewski

Research output: Contribution to journalReviewResearchpeer-review

126 Citations (Scopus)

Abstract

The energy/fuel sensor 5'-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible interplay between AMPK and insulin signaling regulating these processes.
Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume366
Issue number2
Pages (from-to)204-214
Number of pages11
ISSN0303-7207
DOIs
Publication statusPublished - 2013

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