Exercise training alters the balance between vasoactive compounds in skeletal muscle of individuals with essential hypertension

Ane Håkansson Hansen, Michael Permin Nyberg, Jens Bangsbo, Bengt Saltin, Ylva Hellsten

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    Abstract

    The effects of physical training on the formation of vasodilating and vasoconstricting compounds, as well as on related proteins important for vascular function, were examined in skeletal muscle of individuals with essential hypertension (n=10). Muscle microdialysis samples were obtained from subjects with hypertension before and after 16 weeks of physical training. Muscle dialysates were analyzed for thromboxane A(2), prostacyclin, nucleotides, and nitrite/nitrate. Protein levels of thromboxane synthase, prostacyclin synthase, cyclooxygenase 1 and 2, endothelial nitric oxide synthase (eNOS), cystathionine-¿-lyase, cytochrome P450 4A and 2C9, and the purinergic receptors P2X1 and P2Y2 were determined in skeletal muscle. The protein levels were compared with those of normotensive control subjects (n=12). Resting muscle dialysate thromboxane A(2) and prostacyclin concentrations were lower (P
    Original languageEnglish
    JournalHypertension
    Volume58
    Issue number5
    Pages (from-to)943-949
    Number of pages7
    ISSN0194-911X
    DOIs
    Publication statusPublished - 2011

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