Abstract
Neurexins are neuronal adhesion molecules located in the presynaptic terminal, where they interact with postsynaptic neuroligins to form a transsynaptic complex required for efficient neurotransmission in the brain. Recently, deletions and point mutations of the neurexin 1 (NRXN1) gene have been associated with a broad spectrum of neuropsychiatric disorders. This study aimed to investigate if NRXN1 deletions also increase the risk of idiopathic generalized epilepsies (IGEs).
Original language | English |
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Journal | Epilepsia |
Volume | 54 |
Issue number | 2 |
Pages (from-to) | 256-64 |
Number of pages | 9 |
ISSN | 0013-9580 |
DOIs | |
Publication status | Published - Feb 2013 |
Keywords
- Adult
- Age of Onset
- Anticonvulsants
- Case-Control Studies
- Cell Adhesion Molecules, Neuronal
- DNA Copy Number Variations
- Electroencephalography
- Epilepsy, Generalized
- Exons
- Family
- Female
- Fructose
- Gene Deletion
- Genotype
- Humans
- Infant
- Male
- Microarray Analysis
- Middle Aged
- Nerve Tissue Proteins
- Neuropsychological Tests
- Odds Ratio
- Pedigree
- Triazines
- Valproic Acid